Article (Scientific journals)
BLV: lessons on vaccine development
Abdala, Alejandro; Alvarez, Irene; Brossel, Hélène et al.
2019In Retrovirology, 2019 (16), p. 26
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Keywords :
BLV; Vaccine; HTLV; Leukemia; Retrovirus
Abstract :
[en] Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since clearance of the virus is almost impossible once infection is established, the primary goal is to achieve sterilizing immunity. Besides efcacy, safety is the major issue since vaccination has been associated with increased infection or reversion to pathogenicity. In this review, we discuss the diferent issues that we faced during the development of an efcient vaccine against bovine leukemia virus (BLV). We summarize the historical failures of inactivated vaccines, the efcacy and safety of a live-attenuated vaccine and the economical constraints of further industrial development.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Abdala, Alejandro
Alvarez, Irene
Brossel, Hélène ;  Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics
Calvinho, Luis
Carignano, Hugo
Franco, Lautaro
Gazon, Hélène ;  Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics
Gillissen, Christelle ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie
Hamaïdia, Malik  ;  Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics
Hoyos, Clotilde ;  Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics
Jacques, Jean-Rock  ;  Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Microbial, food and biobased technologies
Laval, Florent  ;  Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics
Petersen, Marcos
Porquet, Florent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie
Porta, Natalia
Ruiz, Vanesa
Safari, Roghaiyeh ;  Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics
Suárez Archilla, Guillermo
Trono, Karina
Willems, Luc  ;  Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics
More authors (11 more) Less
Language :
English
Title :
BLV: lessons on vaccine development
Publication date :
2019
Journal title :
Retrovirology
eISSN :
1742-4690
Publisher :
Springer
Volume :
2019
Issue :
16
Pages :
26
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Télévie [BE]
FAC - Belgian Foundation against Cancer
Fondation Léon Fredericq [BE]
INTA - National Institute of Agriculture Technology
CONICET - Consejo Nacional de Investigaciones Científicas y Técnicas [AR]
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