BLV: lessons on vaccine development

[en] Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since clearance of the virus is almost impossible once infection is established, the primary goal is to achieve sterilizing immunity. Besides efcacy, safety is the major issue since vaccination has been associated with increased infection or reversion to pathogenicity. In this review, we discuss the diferent issues that we faced during the development of an efcient vaccine against bovine leukemia virus (BLV). We summarize the historical failures of inactivated vaccines, the efcacy and safety of a live-attenuated vaccine and the economical constraints of further industrial development.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Abdala, Alejandro

Alvarez, Irene

Brossel, Hélène ; Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics

Calvinho, Luis

Carignano, Hugo

Franco, Lautaro

Gazon, Hélène ; Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics

Gillissen, Christelle ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie

Hamaïdia, Malik ; Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics

Hoyos, Clotilde ; Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics

More authors (11 more)

Language :

English

Title :

BLV: lessons on vaccine development

Publication date :

2019

Journal title :

Retrovirology

eISSN :

1742-4690

Publisher :

Springer

Volume :

2019

Issue :

Pages :

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Télévie [BE]
FAC - Belgian Foundation against Cancer
Fondation Léon Fredericq [BE]
INTA - National Institute of Agriculture Technology
CONICET - Consejo Nacional de Investigaciones Científicas y Técnicas [AR]

Available on ORBi :

since 24 October 2019

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