[en] Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since clearance of the virus is almost impossible once infection is established, the primary goal is to achieve sterilizing immunity. Besides efcacy, safety is the major issue since vaccination has been associated with increased infection or reversion to pathogenicity. In this review, we discuss the diferent issues that we faced during the development of an efcient vaccine against bovine leukemia virus (BLV). We summarize the historical failures of inactivated vaccines, the efcacy and safety of a live-attenuated vaccine and the economical constraints of further industrial development.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Abdala, Alejandro
Alvarez, Irene
Brossel, Hélène ; Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics
Calvinho, Luis
Carignano, Hugo
Franco, Lautaro
Gazon, Hélène ; Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics
Gillissen, Christelle ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie
Hamaïdia, Malik ; Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics
Hoyos, Clotilde ; Université de Liège - ULiège > Cancer-Cellular and Molecular Epigenetics
Jacques, Jean-Rock ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Microbial, food and biobased technologies
F.R.S.-FNRS - Fonds de la Recherche Scientifique Télévie FAC - Belgian Foundation against Cancer Fondation Léon Fredericq INTA - National Institute of Agriculture Technology CONICET - Consejo Nacional de Investigaciones Científicas y Técnicas
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
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