Article (Scientific journals)
Evolution of the slopes of ST2 and galectin-3 during marathon and ultratrail running compared to a control group
LE GOFF, Caroline; Kaux, Jean-François; Farre Segura, Jordi et al.
2020In Clinical Chemistry and Laboratory Medicine, 58 (2), p. 314-321
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Keywords :
ST2; fibrosis cardiac biomarkers; galectin-3; long distance running; marathon; running; ultratour
Abstract :
[en] Background Previous studies have suggested that exercising may induce cardiac damage. Galectin-3 (Gal-3) and soluble suppression of tumorigenicity 2 (ST2) are very interesting biomarkers for heart failure and myocardial fibrosis. We aimed to compare the kinetics of emerging fibrosis cardiac biomarkers as Gal-3 and ST-2 in endurance runners, and recreational runners before and after a running event represented by a marathon and an ultratrail event. Methods Blood samples were taken from 19 healthy non-elite marathon runners (42 km), 27 ultratour runners (67 km), and 14 recreational runners who represented the control group (10 km) just before the run (T0), just after (T1) and 3 h after (T2), in order to analyze Gal-3, ST2, hsTnT, NT-proBNP, CKMB and hsCRP. We compared the percentage of evolution and the slopes obtained from T0 to T1 (pT0T1) and from T1 to T2 (pT1T2), between the different groups of runners participating in three different races. Results Plasma cardiac biomarker concentrations increased significantly from baseline to immediately post-exercise and most of the time decreased over the subsequent 3-h period. For pT0T1 and pT1T2, the markers Gal-3 and ST2 showed a significant difference between types of run (p < 0.05 and p < 0.0001, respectively). During the recovery time, Gal-3 returned to the baseline values but not ST2 which continued to increase. Conclusions Gal-3 and ST2 are considered as a reflection of cardiac fibrosis and remodeling. The evolution of both was different, particularly after the recovery time. ST2 values exceeding cutoff values at any time.
Disciplines :
Orthopedics, rehabilitation & sports medicine
Laboratory medicine & medical technology
Author, co-author :
LE GOFF, Caroline  ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire techniques séparatives et stress oxydant
Kaux, Jean-François  ;  Université de Liège - ULiège > Département des sciences de la motricité > Département des sciences de la motricité
Farre Segura, Jordi  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
STOJKOVIC, Violeta ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Pool assistant - biologie clinique
ANCION, Arnaud  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Insuffisance cardiaque - Transplantation
SEIDEL, Laurence  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gestion des systèmes d'informations (GSI) > Secteur d'appui à la recherche clinique et biostatistique
Lancellotti, Patrizio  ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Cavalier, Etienne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Evolution of the slopes of ST2 and galectin-3 during marathon and ultratrail running compared to a control group
Publication date :
January 2020
Journal title :
Clinical Chemistry and Laboratory Medicine
ISSN :
1434-6621
eISSN :
1437-4331
Publisher :
Walter de Gruyter, Berlin, Germany
Volume :
58
Issue :
2
Pages :
314-321
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 October 2019

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