Collagen Degradation and Formation Are Elevated in Exacerbated COPD Compared With Stable Disease.

[en] BACKGROUND: The role of the extracellular matrix (ECM) structure and remodeling thereof in lung diseases is gaining importance. Pathology-related changes in ECM turnover may result in deleterious changes in lung architecture, leading to disease in the small airways. Here, degradation fragments of type I (C1M), type IV (alpha1 chain, C4M2), and type IV (alpha3 chain, C4Ma3) collagen, all degraded by metalloproteinases and the pro-form of collagen type V (PRO-C5) were investigated and associated with COPD severity and outcome. METHODS: In a prospective, observational, multicenter study including 498 patients with COPD Gold Initiative for Chronic Obstructive Lung Disease stage 2 to 4, ECM markers were assessed in serum at stable state, exacerbation, and at follow-up 4 weeks after exacerbation. RESULTS: At stable state, there was a significant inverse association between FEV1 % predicted and C1M, C4Ma3, and Pro-C5. C1M, C4M2, C4Ma3, and Pro-C5 were associated with BMI, airflow obstruction, dyspnea, and exercise capacity (BODE) index and the modified Medical Research Council (MMRC) score. C1M, C4M2, C4Ma3, and Pro-C5 were significantly increased from stable state to exacerbation and decreased at follow-up. Furthermore, the biomarkers were significantly higher during severe exacerbation compared with moderate exacerbation. Multivariate analysis adjusted for BMI, MMRC score, unadjusted Charlson score, and FEV1 %predicted showed a significant influence of C1M, C4Ma3, and C4M2 on time to exacerbation. None of the biomarkers were predictors for mortality. CONCLUSIONS: Serologically assessed collagen remodeling appears to play a significant role in COPD severity (airflow limitation, dyspnea) and disease outcome (time to exacerbation and prognosis as assessed by the BODE index).

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Schumann, Desiree M.

Leeming, Diana

Papakonstantinou, Eleni

Blasi, Francesco

Kostikas, Konstantinos

Boersma, Wim

Louis, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie

Milenkovic, Branislava

Aerts, Joachim

Sand, Jannie M. B.

More authors (8 more)

Language :

English

Title :

Collagen Degradation and Formation Are Elevated in Exacerbated COPD Compared With Stable Disease.

Publication date :

October 2018

Journal title :

CHEST

ISSN :

0012-3692

eISSN :

1931-3543

Publisher :

Elsevier, United States - Illinois

Volume :

154

Issue :

Pages :

798-807

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 12 October 2019

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