First report of a successful pediatric heart transplantation from donation after circulatory death with distant procurement using normothermic regional perfusion and cold storage.
2019 • In The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 38 (10), p. 1112-1115
cold static storage; donation after circulatory death; heart transplantation; normothermic regional perfusion; organ donation; organ transplantation
Abstract :
[en] Heart transplantation (HT) from donation after circulatory death (DCD) is a promising alternative to expand the heart donor pool. Cold storage can be used in a strategy to successfully retrieve and transplant DCD hearts after reconditioning using normothermic regional perfusion for distant procurement. Herein, we present the first report of a pediatric DCD heart reconditioned with normothermic regional perfusion, preserved using only cold storage while being transported to a neighboring center, and then successfully transplanted after nearly 2 hours of cold static storage. If supported by an appropriate trial, this finding could obviate the need to use expensive perfusion devices for short interhospital distances for DCD heart transportation and stimulate more centers across the world to embrace DCD HT.
Disciplines :
Anesthesia & intensive care Cardiovascular & respiratory systems Surgery
Author, co-author :
Tchana-Sato, Vincent ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Ledoux, Didier ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Vandendriessche, Katrien
Van Cleemput, Johan
Hans, Grégory ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
ANCION, Arnaud ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Insuffisance cardiaque - Transplantation
Cools, Bjorn
AMABILI, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation
DETRY, Olivier ; Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Chirurgie abdo, sénologique, endocrine et de transplantation
MASSION, Paul ; Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service des soins intensifs
MONARD, Josée ; Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Chirurgie abdo, sénologique, endocrine et de transplantation
DELBOUILLE, Marie-Hélène ; Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Chirurgie abdo, sénologique, endocrine et de transplantation
Meyns, Bart
Defraigne, Jean-Olivier ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
First report of a successful pediatric heart transplantation from donation after circulatory death with distant procurement using normothermic regional perfusion and cold storage.
Publication date :
October 2019
Journal title :
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
ISSN :
1053-2498
eISSN :
1557-3117
Volume :
38
Issue :
10
Pages :
1112-1115
Peer reviewed :
Peer reviewed
Commentary :
Copyright (c) 2019 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
Smits JM, De Pauw M, Delmo Walter E, et al. Pediatric heart allocation and transplantation in Eurotransplant. Transpl Int2014;27:917-25.
Dhital KK, Iyer A, Connellan M, et al. Adult heart transplantation with distant procurement and ex-vivo preservation of donor hearts after circulatory death: a case series. Lancet2015;385:2585-91.
Tchana-sato V, Ledoux D, Detry O, et al. Successful clinical transplantation of hearts donated after circulatory death using normothermic regional perfusion. J Heart Lung Transplant2019;38:593-8.
Joris J, Kaba A, Lauwick S, et al. End of life care in the operating room for non-heart beating donors: organization at the University Hospital of Liege. Transplant Proc2011;43:3441-4.
Ledoux D, Delbouille MH, Deroover A, et al. Does comfort therapy during controlled donation after circulatory death shorten the life of potential donors?Clin Transpl2014;28:47-51.
Boucek MM, Mashburn C, Dunn SM, et al. Pediatric heart transplantation after declaration of cardiocirculatory death. N Engl J Med2008;359:709-14.
Messer SJ, Axell RG, Colah S, et al. Functional assessment and transplantation of the donor heart after circulatory death. J Heart Lung Transplant2016;35:1443-52.
Messer S, Page A, Colah S, et al. Human heart transplantation from donation after circulatory-determined death donors using normothermic regional perfusion and cold storage. J Heart Lung Transplant2018;37:865-9.
Tsui SSL, Oniscu GC.Extending normothermic regional perfusion to the thorax in donors after circulatory death. Curr Opin Organ Transplant2017;22:245-50.
Kleinmahon JA, Patel SS, Auerbach SR, Rossano J, Everitt MD. Hearts transplanted after circulatory death in children: analysis of the international society for heart and lung transplantation registry. Pediatr Transplant2017;21:13064.