Article (Scientific journals)
Le medicament du mois Trimbow(R) ou triple association bronchodilatatrice et anti-inflammatoire en aérosol dans la broncho-pneumopathie chronique obstructive
Corhay, Jean-Louis; BONHOMME, Olivier; GUIOT, Julien
2018In Revue Médicale de Liège, 73 (9), p. 480-484
Peer reviewed
 

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Keywords :
Administration, Inhalation; Adrenergic beta-2 Receptor Agonists/administration & dosage; Bronchodilator Agents/administration & dosage; Drug Combinations; Glucocorticoids/administration & dosage; Humans; Muscarinic Antagonists/administration & dosage; Pulmonary Disease, Chronic Obstructive/drug therapy; Bronchodilator; Chronic obstructive pulmonary disease; Exacerbation; Triple therapy
Abstract :
[en] Single-inhaler triple therapy in extrafine solution combining an inhaled corticosteroid (ICS), the dipropionate of beclometasone, a long acting ss2-agonist (LABA), the fumarate of formoterol and an long-acting muscarinic antagonist (LAMA), the bromide of glycopyrronium, was developed for the treatment of the chronic obstructive pulmonary disease (COPD). Trimbow(R) is the first triple therapy in spray with fixed dose and containing 3 pharmacological agents (LABA-LAMA-ICS). Clinical trials show that Trimbow(R) improves numerous parameters such as the respiratory function, the quality of life, the symptoms and the rate of moderate to severe exacerbations while being tolerated well. These results justify its use in severe and very severe COPD with exacerbations in spite of treatment by LABA-LAMA or LABA-ICS. In this article, we present a brief synthesis of the main recent clinical trials on Trimbow(R), its comparison with other pharmacological agents/associations regularly used in the treatment of COPD, as well as some practical information on its use in routine.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Corhay, Jean-Louis ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
BONHOMME, Olivier ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Unité des soins intensifs médicaux
GUIOT, Julien  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie - allergologie
Language :
French
Title :
Le medicament du mois Trimbow(R) ou triple association bronchodilatatrice et anti-inflammatoire en aérosol dans la broncho-pneumopathie chronique obstructive
Alternative titles :
[en] Trimbow(R) : twice-daily triple combination for the treatment of COPD
Publication date :
2018
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Belgium
Volume :
73
Issue :
9
Pages :
480-484
Peer reviewed :
Peer reviewed
Available on ORBi :
since 27 September 2019

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