Article (Scientific journals)
Chitosan-g-Polyester Microspheres: Effect of Length and Composition of Grafted Chains
Demina, T. S.; Sevrin, Chantal; Kapchiekue, C. et al.
2019In Macromolecular Materials and Engineering
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Keywords :
Chitosan; Emulsification; Graft copolymers; Hydrophilicity; Hydrophobicity; Morphology; Ring opening polymerization; Surface morphology; Terpolymers; Tissue engineering; Fluorescein isothiocyanate; Hydrophilic and hydrophobic; Micro-particles; Microparticle surfaces; Oil/water emulsion; Oil/water interfaces; Poly lactide; Polyester microspheres; Microspheres
Abstract :
[en] Hydrophobic segments made of oligo(l,l- or d,l-lactides) or poly(l,l-lactide) are grafted onto chitosan backbone in order to use their amphiphilic behavior to prepare degradable microcarriers intended to be used for tissue engineering. Hydrophilic–lipophilic balance of these copolymers is adjusted playing on the respective length of their hydrophilic and hydrophobic moieties. Thanks to their self-emulsifying properties, these graft copolymers are processed into microspheres in the absence of hydrophilic emulsifier commonly added in the aqueous phase of the oil/water emulsion. The copolymers containing amorphous oligolactide segments of medium length are demonstrated to be the most effective ones for microparticle fabrication. The microparticles are characterized using SEM, EDX, and FTIR. The reactivity of amine group is demonstrated using fluorescein isothiocyanate staining. The resulting microspheres disclose a porous core and a shell enriched by the hydrophilic polysaccharide moieties. Stabilization of the oil/water interface during the microsphere fabrication, total yield, size distribution, and microparticle surface morphology are mainly affected by the macromolecular features of the copolymers. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Research center :
CEIB - Centre Interfacultaire des Biomatériaux - ULiège
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Demina, T. S.;  Enikolopov Institute of Synthetic Polymeric Materials of Russian Academy of Sciences (ISPM RAS), Profsoyuznaya str. 70Moscow 117393, Russian Federation, Institute for Regenerative Medicine, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya str.Moscow 119991, Russian Federation
Sevrin, Chantal ;  Université de Liège - ULiège > CEIB
Kapchiekue, C.;  Interfaculty Research Centre on Biomaterials (CEIB), University of Liège, Chemistry Institute, B6C, Liege, Sart-Tilman B-4000, Belgium
Akopova, T. A.;  Enikolopov Institute of Synthetic Polymeric Materials of Russian Academy of Sciences (ISPM RAS), Profsoyuznaya str. 70Moscow 117393, Russian Federation
Grandfils, Christian ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Language :
English
Title :
Chitosan-g-Polyester Microspheres: Effect of Length and Composition of Grafted Chains
Publication date :
2019
Journal title :
Macromolecular Materials and Engineering
ISSN :
1438-7492
eISSN :
1439-2054
Publisher :
Wiley-VCH Verlag
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Russian Federation. Ministry of Education and Science [RU]
WBI - Wallonie-Bruxelles International [BE]
ULiège - Université de Liège [BE]
Available on ORBi :
since 25 September 2019

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