Non-targeted analysis of the particulate phase of heated tobacco product aerosol and cigarette mainstream tobacco smoke by thermal desorption comprehensive two-dimensional gas chromatography with dual flame ionisation and mass spectrometric detection
Savareear, Benjamin; Escobar Arnanz, Juan; Brokl, Met al.
2019 • In Journal of Chromatography. A, 1603, p. 327-337
Savareear, Benjamin ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique, organique et biologique
Escobar Arnanz, Juan ; Université de Liège > Département de chimie (sciences) > Chimie analytique, organique et biologique
Brokl, M
Saxton, M
Wright, C
Liu, C
Focant, Jean-François ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique, organique et biologique
Language :
English
Title :
Non-targeted analysis of the particulate phase of heated tobacco product aerosol and cigarette mainstream tobacco smoke by thermal desorption comprehensive two-dimensional gas chromatography with dual flame ionisation and mass spectrometric detection
Borgerding, M., Klus, H., Analysis of complex mixtures - cigarette smoke. Exp. Toxicol. Pathol. 57 (2005), 43–73.
Smith, C.J., Perfetti, T.A., Garg, R., Hansch, C., IARC carcinogens reported in cigarette mainstream smoke and their calculated log P values. Food Chem. Toxicol. 41 (2003), 807–817.
Wakeham, H., Proceedings of the symposium on the chemical composition of tobacco and tobacco smoke. Schmeltz, I., (eds.) 162nd National Meeting, American Chemical Society, Washington, DC, September 1971, 1972, 1.
Marco, E., Grimalt, J.O., A rapid method for the chromatographic analysis of volatile organic compounds in exhaled breath of tobacco cigarette and electronic cigarette smokers. J. Chromatogr. A 1410 (2015), 51–59.
Poynton, S., Sutton, J., Goodall, S., Margham, J., Forster, M., Scott, K., Liu, C., McAdam, K., Murphy, J., Proctor, C., A novel hybrid tobacco product that delivers a tobacco flavour note with vapour aerosol (Part 1): product operation and preliminary aerosol chemistry assessment. Food Chem. Toxicol. 106 (2017), 522–532.
Savareear, B., Lizak, R., Brokl, M., Wright, C., Liu, C., Focant, J.-F., Headspace solid-phase microextraction coupled to comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry for the analysis of aerosol from tobacco heating product. J. Chromatogr. A 1520 (2017), 135–142.
Forster, M., Fiebelkorn, S., Yurteri, C., Mariner, D., Liu, C., Wright, C., McAdam, K., Murphy, J., Proctor, C., Assessment of novel tobacco heating product THP1.0. Part 3: comprehensive chemical characterisation of harmful and potentially harmful aerosol emissions. Regul. Toxicol. Pharmacol. 93 (2018), 14–33.
Bekki, K., Inaba, Y., Uchiyama, S., Kunugita, N., Comparison of chemicals in mainstream smoke in heat-not-burn tobacco and combustion cigarettes. J. UOEH 39 (2017), 201–207.
Schaller, J.P., Pijnenburg, J.P.M., Ajithkumar, A., Tricker, A.R., Evaluation of the Tobacco Heating System 2.2. Part 3: influence of the tobacco blend on the formation of harmful and potentially harmful constituents of the Tobacco Heating System 2.2 aerosol. Regul. Toxicol. Pharmacol. 81 (2016), S48–S58.
Li, X., Luo, Y., Jiang, X., Zhang, H., Zhu, F., Hu, S., Hou, H., Hu, Q., Pang, Y., Chemical analysis and simulated pyrolysis of tobacco heating system 2.2 compared to conventional cigarettes. Nicotine Tob. Res., 2018, 1–8.
Lu, X., Zhao, M., Kong, H., Cai, J., Wu, J., Wu, M., Hua, R., Liu, J., Xu, G., Characterization of cigarette smoke condensates by comprehensive two-dimensional gas chromatography / time-of-flight mass spectrometry Part 2 : basic fraction. J. Sep. Sci. 27 (2004), 101–109.
Lu, X., Cai, J., Kong, H., Wu, M., Hua, R., Zhao, M., Liu, J., Xu, G., Analysis of cigarette smoke condensates by comprehensive two-dimensional gas chromatography / time-of-Flight mass spectrometry I acidic fraction. Anal. Chem. 75 (2003), 4441–4451.
Clark, T.J., Bunch, J.E., Quantitative determination of phenols in mainstream smoke withsolid - phase microextraction - gas chromatography - selected ionmonitoring mass spectrometry. J. Chromatogr. Sci. 34 (1996), 272–275.
Brokl, M., Bishop, L., Wright, C.G., Liu, C., McAdam, K., Focant, J.F., Analysis of mainstream tobacco smoke particulate phase using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry. J. Sep. Sci. 36 (2013), 1037–1044.
Wang, X., Wang, Y., Qin, Y., Ding, L., Chen, Y., Xie, F., Sensitive and selective determination of polycyclic aromatic hydrocarbons in mainstream cigarette smoke using a graphene-coated solid-phase microextraction fiber prior to GC/MS. Talanta 140 (2015), 102–108.
Brokl, M., Bishop, L., Wright, C.G., Liu, C., McAdam, K., Focant, J.F., Multivariate analysis of mainstream tobacco smoke particulate phase by headspace solid-phase micro extraction coupled with comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry. J. Chromatogr. A 1370 (2014), 216–229.
Bao, M., Joza, P., Rickert, W.S., Lauterbach, J.H., An improved headspace solid-phase microextraction method for the analysis of free-base nicotine in particulate phase of mainstream cigarette smoke. Anal. Chim. Acta 663 (2010), 49–54.
Dallüge, J., van Stee, L.L., Xu, X., Williams, J., Beens, J., Vreuls, R.J., Brinkman, U.A.T., Unravelling the composition of very complex samples by comprehensive gas chromatography coupled to time-of-flight mass spectrometry. J. Chromatogr. A 974 (2002), 169–184.
Takanami, Y., Chida, M., Hasebe, H., Sone, Y., Suhara, S., Analysis of cigarette smoke by an online thermal desorption system and multidimensional GC-MS. J. Chromatogr. Sci. 41 (2003), 317–322.
Woolfenden, E., Sorbent-based sampling methods for volatile and semi-volatile organic compounds in air. Part 1: sorbent-based air monitoring options. J. Chromatogr. A 1217 (2010), 2674–2684.
Stefanuto, P.-H., Perrault, K., Stadler, S., Pesesse, R., Brokl, M., Forbes, S., Focant, J.-F., Reading cadaveric decomposition chemistry with a new pair of glasses. Chempluschem. 79 (2014), 786–789.
Stadler, S., Stefanuto, P.-H., Brokl, M., Forbes, S.L., Focant, J.-F., Characterization of volatile organic compounds from human analogue decomposition using thermal desorption coupled to comprehensive two-dimensional gas chromatography–Time-of-Flight mass spectrometry. Anal. Chem. 85 (2013), 998–1005.
Forbes, S.L., Perrault, K.A., Stefanuto, P.-H., Nizio, K.D., Focant, J.F., Comparison of the decomposition VOC profile during winter and summer in a moist, mid-latitude (Cfb) climate. PLoS One 9 (2014), 1–11.
Savareear, B., Brokl, M., Wright, C., Focant, J.-F., Thermal desorption comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry for vapour phase mainstream tobacco smoke analysis. J. Chromatogr. A 1525 (2017), 126–137.
Savareear, B., Escobar-Arnanz, J., Brokl, M., Saxton, M.J., Wright, C., Liu, C., Focant, J.-F., Comprehensive comparative compositional study of the vapour phase of cigarette mainstream tobacco smoke and tobacco heating product aerosol. J. Chromatogr. A, 2018, 1581–1582.
Stefanuto, P.-H., Perrault, K.A., Dubois, L.M., Homme, B.L., Allen, C., Loughnane, C., Ochiai, N., Advanced method optimization for volatile aroma profiling of beer using two-dimensional gas chromatography time-of-flight mass spectrometry. J. Chromatogr. A 1507 (2017), 45–52.
Dubois, L.M., Perrault, K.A., Stefanuto, P.-H., Koschinski, S., Edwards, M., McGregor, L., Focant, J.-F., Thermal desorption comprehensive two-dimensional gas chromatography coupled to variable-energy electron ionization time-of-flight mass spectrometry for monitoring subtle changes in volatile organic compound profiles of human blood. J. Chromatogr. A 1501 (2017), 117–127.
Stefanuto, P.-H., Perrault, K.A., Stadler, S., Pesesse, R., Leblanc, H.N., Forbes, S.L., Focant, J., RESEARCH PAPER GC × GC – TOFMS and supervised multivariate approaches to study human cadaveric decomposition olfactive signatures. Anal. Bioanal. Chem., 2015, 4767–4778.
Nicolotti, L., Cordero, C., Bressanello, D., Cagliero, C., Liberto, E., Magagna, F., Rubiolo, P., Sgorbini, B., Bicchi, C., Parallel dual secondary column-dual detection: a further way of enhancing the informative potential of two-dimensional comprehensive gas chromatography. J. Chromatogr. A 1360 (2014), 264–274.
Eaton, D., Jakaj, B., Forster, M., Nicol, J., Mavropoulou, E., Scott, K., Liu, C., McAdam, K., Murphy, J., Proctor, C.J., Assessment of tobacco heating product THP1.0. Part 2: product design, operation and thermophysical characterisation. Regul. Toxicol. Pharmacol. 93 (2018), 4–13.
Health Canada Method T-115, Determination of “Tar”, Nicotine and Carbon Monoxide in Mainstream Tobacco Smoke. 1999, Health Canada, Ottawa.
ISO 3308, Routine Analytical Smoking Machine-Definition and Standard Conditions. 2000, International Organisation for Standardisation, Geneva.
Linear Retention Indices. 2019 database onlines: https://www.ncbi.nlm.nih.gov/pccompound?cmd=search (Accessed 20 March 2018).
Mommers, J., Ritzen, E., Dutriez, T., van der Wal, S., A procedure for comprehensive two-dimensional gas chromatography retention time locked dual detection. J. Chromatogr. A 1461 (2016), 153–160.
Semard, G., Peulon-Agasse, V., Bruchet, A., Bouillon, J.P., Cardinaël, P., Convex hull: a new method to determine the separation space used and to optimize operating conditions for comprehensive two-dimensional gas chromatography. J. Chromatogr. A 1217 (2010), 5449–5454.
Paulina de la Mata, A., Nizio, K.D., Harynuk, J.J., Integration parameters and their effects on quantitative results with two-step peak summation quantitation in comprehensive two-dimensional gas chromatography. J. Chromatogr. A 1255 (2012), 190–195.
Hoffmann, D., Hoffmann, I., Letters to the editor, tobacco smoke components. Beitr. Tabaksforsch. Int. 18 (1998), 49–52.