Article (Scientific journals)
Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer.
Bieniasz-Krzywiec, Pawel; Martin-Perez, Rosa; Ehling, Manuel et al.
2019In Cell Metabolism
Peer Reviewed verified by ORBi


Full Text
Bieniasz-Krzywiec 2019.pdf
Publisher postprint (8.54 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to


Keywords :
breast cancer; lymph nodes; lymphangiogenesis; lymphoinvasion; metastasis; podoplanin; tumor-associated macrophages
Abstract :
[en] Among mammary tumor-infiltrating immune cells, the highest expression of podoplanin (PDPN) is found in a subset of tumor-associated macrophages (TAMs). We hereby demonstrate that PDPN is involved in the attachment of this TAM subset to lymphatic endothelial cells (LECs). Mechanistically, the binding of PDPN to LEC-derived galectin 8 (GAL8) in a glycosylation-dependent manner promotes the activation of pro-migratory integrin beta1. When proximal to lymphatics, PDPN-expressing macrophages (PoEMs) stimulate local matrix remodeling and promote vessel growth and lymphoinvasion. Anti-integrin beta1 blockade, macrophage-specific Pdpn knockout, or GAL8 inhibition impairs TAM adhesion to LECs, restraining lymphangiogenesis and reducing lymphatic cancer spread. In breast cancer patients, association of PoEMs with tumor lymphatic vessels correlates with incidences of lymph node and distant organ metastasis.
Disciplines :
Author, co-author :
Bieniasz-Krzywiec, Pawel
Martin-Perez, Rosa
Ehling, Manuel
Garcia-Caballero, Melissa
Pinioti, Sotiria
Pretto, Samantha
Kroes, Roel
Aldeni, Chiara
Di Matteo, Mario
Prenen, Hans
Tribulatti, Maria Virginia
Campetella, Oscar
Smeets, Ann
Noël, Agnès ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Floris, Giuseppe
Van Ginderachter, Jo A.
Mazzone, Massimiliano
More authors (7 more) Less
Language :
Title :
Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer.
Publication date :
Journal title :
Cell Metabolism
Publisher :
Cell Press, United States
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2019 Elsevier Inc. All rights reserved.
Available on ORBi :
since 03 September 2019


Number of views
71 (1 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
Scopus citations®
without self-citations


Similar publications

Contact ORBi