Reference : MR-spectroscopic imaging during visual stimulation in subgroups of migraine with aura
Scientific journals : Article
Human health sciences : Neurology
Social & behavioral sciences, psychology : Neurosciences & behavior
MR-spectroscopic imaging during visual stimulation in subgroups of migraine with aura
Sandor, P. S. [> > > >]
Dydak, U. [> > > >]
Schoenen, Jean mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie]
Kollias, S. [> > > >]
Hess, K. [> > > >]
Boesiger, P. [> > > >]
Agosti, R. M. [> > > >]
Blackwell Science
Yes (verified by ORBi)
[en] lactate ; metabolism ; migraine ; MRS ; visual stimultion
[en] Migraine pathophysiology possibly involves deficient mitochondrial energy reserve and diminished cortical habituation. Using functional magnetic resonance spectroscopic imaging (fMRSI), we studied cortical lactate changes during prolonged visual stimulation to search for different pathophysiological mechanisms in clinically distinct subgroups of migraine with aura. Eleven healthy volunteers (HV) and 10 migraine patients were investigated interictally: five with visual aura (MA) and five with visual symptoms and at least one of the following: paraesthesia, paresis or dysphasia (MAplus). Using MRSI (Philips, 1.5 T) H-1-spectra were repeatedly obtained from a 25 mm-thick slice covering visual and non-visual cortex, with the first and fifth measurements in darkness and the second to fourth with 8-Hz checkerboard stimulation. In MAplus lactate increased only during stimulation, only in visual cortex; in MA resting lactate was high in visual cortex, without further increase during stimulation. This is compatible with an abnormal metabolic strain during stimulation in MAplus, possibly due to dishabituation, and a predominant mitochondrial dysfunction in MA.

File(s) associated to this reference

Fulltext file(s):

Restricted access
Mr-spectroscopic imaging Sandor et al 05.pdfPublisher postprint351.38 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.