Article (Scientific journals)
Connectivity differences between consciousness and unconsciousness in non-rapid eye movement sleep: a TMS-EEG study.
Lee, Minji; Baird, Benjamin; Gosseries, Olivia et al.
2019In Scientific Reports, 9 (1), p. 5175
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Abstract :
[en] The neuronal connectivity patterns that differentiate consciousness from unconsciousness remain unclear. Previous studies have demonstrated that effective connectivity, as assessed by transcranial magnetic stimulation combined with electroencephalography (TMS-EEG), breaks down during the loss of consciousness. This study investigated changes in EEG connectivity associated with consciousness during non-rapid eye movement (NREM) sleep following parietal TMS. Compared with unconsciousness, conscious experiences during NREM sleep were associated with reduced phase-locking at low frequencies (<4 Hz). Transitivity and clustering coefficient in the delta and theta bands were also significantly lower during consciousness compared to unconsciousness, with differences in the clustering coefficient observed in scalp electrodes over parietal-occipital regions. There were no significant differences in Granger-causality patterns in frontal-to-parietal or parietal-to-frontal connectivity between reported unconsciousness and reported consciousness. Together these results suggest that alterations in spectral and spatial characteristics of network properties in posterior brain areas, in particular decreased local (segregated) connectivity at low frequencies, is a potential indicator of consciousness during sleep.
Disciplines :
Neurosciences & behavior
Author, co-author :
Lee, Minji
Baird, Benjamin
Gosseries, Olivia  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Nieminen, Jaakko O.
Boly, Melanie
Postle, Bradley R.
Tononi, Giulio
Lee, Seong-Whan
Language :
English
Title :
Connectivity differences between consciousness and unconsciousness in non-rapid eye movement sleep: a TMS-EEG study.
Publication date :
2019
Journal title :
Scientific Reports
eISSN :
2045-2322
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
9
Issue :
1
Pages :
5175
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 August 2019

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