Article (Scientific journals)
Determinants, consequences and potential solutions to poor adherence to anti-osteoporosis treatment: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Osteoporosis Foundation (IOF)
Hiligsmann, M.; Cornelissen, D.; Vrijens, Bernard et al.
2019In Osteoporosis International, 30 (11), p. 2155-2165
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Keywords :
Adherence; Determinants; Osteoporosis; Persistence; Solutions
Abstract :
[en] Summary: Many patients at increased risk of fractures do not take their medication appropriately, resulting in a substantial decrease in the benefits of drug therapy. Improving medication adherence is urgently needed but remains laborious, given the numerous and multidimensional reasons for non-adherence, suggesting the need formeasurement-guided, multifactorial and individualized solutions. Introduction: Poor adherence to medications is a major challenge in the treatment of osteoporosis. This paper aimed to provide an overview of the consequences, determinants and potential solutions to poor adherence and persistence to osteoporosis medication. Methods: Aworking group was organized by the European Society on Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal diseases (ESCEO) to review consequences, determinants and potential solutions to adherence and to make recommendations for practice and further research. A systematic literature review and a face-to-face experts meeting were undertaken. Results: Medication non-adherence is associated with increased risk of fractures, leading to a substantial decrease in the clinical and economic benefits of drug therapy. Reasons for non-adherence are numerous and multidimensional for each patient, depending on the interplay of multiple factors, suggesting the need for multifactorial and individualized solutions. Few interventions have been shown to improve adherence or persistence to osteoporosis treatment. Promising actions include patient education with counselling, adherence monitoring with feedback and dose simplification including flexible dosing regimen. Recommendations for practice and further research were also provided. To adequately manage adherence, it is important to (1) understand the problem (initiation, implementation and/or persistence), (2) to measure adherence and (3) to identify the reason of non-adherence and fix it. Conclusion: These recommendations are intended for clinicians to manage adherence of their patients and to researchers and policy makers to design, facilitate and appropriately use adherence interventions.
Disciplines :
General & internal medicine
Public health, health care sciences & services
Author, co-author :
Hiligsmann, M.
Cornelissen, D.
Vrijens, Bernard  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Département des sciences de la santé publique
Abrahamsen, B.
Al-Daghri, N.
Biver, E.
Brandi, M.L.
Bruyère, Olivier  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Burlet, N.
Cooper, C.
Cortet, B.
Dennison, E.
Diez-Perez, A.
Gasparik, A.
Grosso, A.
Hadji, P.
Halbout, P.
Kanis, J.A.
Kaufman, J.M.
Laslop, A.
Maggi, S.
Rizzoli, R.
Thomas, T.
Tuzun, S.
Vlaskovska, M.
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
More authors (16 more) Less
Language :
English
Title :
Determinants, consequences and potential solutions to poor adherence to anti-osteoporosis treatment: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Osteoporosis Foundation (IOF)
Publication date :
2019
Journal title :
Osteoporosis International
ISSN :
0937-941X
eISSN :
1433-2965
Publisher :
Springer, Germany
Volume :
30
Issue :
11
Pages :
2155-2165
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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