Reference : Efficacy of the new long-acting formulation of lanreotide (lanreotide Autogel) in the...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/23784
Efficacy of the new long-acting formulation of lanreotide (lanreotide Autogel) in the management of acromegaly.
English
Caron, Ph [ > > ]
Beckers, Albert mailto [Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie >]
Cullen, C. R. [ > > ]
Goth, M. I. [ > > ]
Gutt, B. [ > > ]
Laurberg, P. [ > > ]
Pico, A. M. [ > > ]
Valimaki, M. [ > > ]
Zgliczynski, W. [ > > ]
Jan-2002
Journal of Clinical Endocrinology and Metabolism
Endocrine Society
87
1
99-104
Yes (verified by ORBi)
International
0021-972X
Chevy Chase
MD
[en] Acromegaly/blood/drug therapy ; Chemistry, Pharmaceutical ; Delayed-Action Preparations ; Female ; Hormones/administration & dosage/therapeutic use ; Human Growth Hormone/blood ; Humans ; Injections, Intramuscular ; Injections, Subcutaneous ; Insulin-Like Growth Factor I/analysis ; Male ; Middle Aged ; Peptides, Cyclic/administration & dosage/therapeutic use ; Somatostatin/administration & dosage/analogs & derivatives/therapeutic use
[en] Lanreotide Autogel is a new long-acting aqueous preparation of lanreotide for the treatment of acromegaly and is administered by deep sc injection from a small volume, prefilled syringe. The aim of this study was to evaluate the efficacy and safety of this new long-acting formulation in a large population of acromegalic patients previously responsive to lanreotide 30 mg, im (sustained release microparticle formulation). Lanreotide Autogel was administered by deep sc injection every 28 d to 107 patients (54 males and 53 females; mean age, 54 +/- 1.2 yr). All patients had been treated with lanreotide (30 mg) for at least 3 months before study entry and had a mean GH level less than 10 ng/ml after at least 4 subsequent im injections every 14 d (48%), 10 d (32%), or 7 d (20%). Treatment was switched from lanreotide 30 mg injected every 14, 10, or 7 d to 60, 90, or 120 mg lanreotide Autogel, respectively, every 28 d. After three fixed dose injections of lanreotide Autogel, mean lanreotide levels were similar to those obtained at steady state with lanreotide 30 mg. During lanreotide Autogel treatment, the control of acromegalic symptoms was comparable with that previously achieved during lanreotide 30 mg treatment. After 3 injections of lanreotide Autogel, mean GH (2.87 +/- 0.22 ng/ml) and IGF-I (317 +/- 15 ng/ml) values were comparable with those recorded at the end of lanreotide 30 mg treatment (GH, 2.82 +/- 0.19 ng/ml; IGF-I, 323 +/- 16 ng/ml). GH levels below 2.5 ng/ml and age-/sex-normalized IGF-I were achieved in 33% and 39% of patients during lanreotide 30 mg and lanreotide Autogel treatment, respectively. Diarrhea, abdominal pain, and nausea were reported by 38%, 22%, and 18% of patients during lanreotide 30 mg treatment and by 29%, 17%, and 9% of patients, respectively, during lanreotide Autogel treatment. In conclusion, this clinical study shows that lanreotide Autogel is at least as efficacious and well tolerated as lanreotide 30 mg. This new long-acting lanreotide formulation, lanreotide Autogel, which is administered from a small volume, prefilled syringe by deep sc injection, is therefore likely to improve the acceptability of medical treatment for patients requiring long-term somatostatin analog therapy.
Researchers ; Professionals
http://hdl.handle.net/2268/23784
also: http://hdl.handle.net/2268/23946
10.1210/jc.87.1.99

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Efficacy of the new long-acting formulation of lanreotide (lanreotide Autogel) in the management of acromegaly..pdfPublisher postprint1.18 MBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.