Article (Scientific journals)
SEVERE CUTANEOUS HERPES SIMPLEX VIRUS AND VARICELLA ZOSTER VIRUS LESIONS
EL HAYDERI, Lara; NIKKELS, Arjen
2012In Expert Review of Dermatology, 7 (3), p. 259
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Keywords :
acyclovir; herpes genitalis; herpes labialis; herpes zoster; immunosuppression; severe cutaneous infections; varicella
Abstract :
[en] Herpes simplex viruses 1 and 2 (HSV-1, HSV-2) and varicella zoster virus (VZV) are responsible for recurrent orolabial and genital herpes, as well as chickenpox and shingles, respectively. Severe cutaneous HSV or VZV infections can occur when the systemic host immune reponse is impaired genetically, by immunosuppressive therapy, cancer or human immunodeficiency virus infection. Furthermore, the cutaneous host immune defense can be altered as in atopic dermatitis, or by topical immunosuppressive thérapies, including topical corticosteroids and immune response modifiers. Skin diseases as pemphigus, bullous pemphigoid, cutaneous t-cell lymphomas and Sézary syndrome, Darier's and Grover's disease also predispose to severe cutaneous HSV or VZV infections. Epidermal injury after cosmetic procedures, dental extractions or neurosurgical interventions of the trigeminal ganglion also increase the risk for extended cutaneous viral infection. This article reviews the different local risk factors for severe HSV and VZV skin infection. This article reviews the different local risk factors for severe HSV and VZV skin infections, provides insight in the pathomechanisms and presents treatment recommendations.
Disciplines :
Dermatology
Author, co-author :
EL HAYDERI, Lara ;  Centre Hospitalier Universitaire de Liège - CHU > Service de dermatologie
NIKKELS, Arjen ;  Centre Hospitalier Universitaire de Liège - CHU > Service de dermatologie
Language :
English
Title :
SEVERE CUTANEOUS HERPES SIMPLEX VIRUS AND VARICELLA ZOSTER VIRUS LESIONS
Publication date :
2012
Journal title :
Expert Review of Dermatology
ISSN :
1746-9872
Publisher :
Future Drugs, United Kingdom
Volume :
7
Issue :
3
Pages :
259+
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 June 2019

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