Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

Darby, M. G.; Chetty, A.; Mrjden, D.; Rolot, M.; Smith, K.; MacKowiak, C.; Sedda, D.; Nyangahu, D.; Jaspan, H.; Toellner, K.-M.; Waisman, A.; Quesniaux, V.; Ryffel, B.; Cunningham, A. F.; Dewals, Benjamin G; Brombacher, F.; Horsnell, W. G. C.

doi:10.1126/sciadv.aav3058

Article (Scientific journals)

Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

Darby, M. G.; Chetty, A.; Mrjden, D. et al.

2019 • In Science Advances, 5 (5)

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/237111

DOI
10.1126/sciadv.aav3058

PubMed
31236458

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Keywords :

T-cells; CD4 T-cells; Early life; Long lasting; Maternal exposure; Maternal transfer; Nursing

Abstract :

[en] Maternal immune transfer is the most significant source of protection from early-life infection, but whether maternal transfer of immunity by nursing permanently alters offspring immunity is poorly understood. Here, we identify maternal immune imprinting of offspring nursed by mothers who had a pre-conception helminth infection. Nursing of pups by helminth-exposed mothers transferred protective cellular immunity to these offspring against helminth infection. Enhanced control of infection was not dependent on maternal antibody. Protection associated with systemic development of protective type 2 immunity in T helper 2 (TH2) impaired IL-4R-/- offspring. This maternally acquired immunity was maintained into maturity and required transfer (via nursing) to the offspring of maternally derived TH2-competent CD4 T cells. Our data therefore reveal that maternal exposure to a globally prevalent source of infection before pregnancy provides long-term nursing-acquired immune benefits to offspring mediated by maternally derived pathogen-experienced lymphocytes. © 2019 by the Authors.

Disciplines :

Immunology & infectious disease

Author, co-author :

Darby, M. G.; Institute of Infectious Disease and Molecular Medicine, Division of Immunology, University of Cape Town, Cape Town, 7925, South Africa

Chetty, A.; Institute of Infectious Disease and Molecular Medicine, Division of Immunology, University of Cape Town, Cape Town, 7925, South Africa

Mrjden, D.; Institute of Infectious Disease and Molecular Medicine, Division of Immunology, University of Cape Town, Cape Town, 7925, South Africa, Department of Pathology, Stanford Blood Center, Stanford University, 3373 Hillview Ave., Palo Alto, CA 94304, United States

Rolot, M.; Fundamental and Applied Research in Animals and Health (FARAH), Immunology-Vaccinology, Faculty of Veterinary Medicine (B43b), University of Liège, Liège, Belgium

Smith, K.; Institute of Infectious Disease and Molecular Medicine, Division of Immunology, University of Cape Town, Cape Town, 7925, South Africa, Institute of Infection and Immunity, University of Cardiff, Cardiff, United Kingdom

MacKowiak, C.; Laboratory of Molecular and Experimental Immunology and Neuro-genetics, UMR 7355, CNRS-University of Orleans, Le Studium Institute for Advanced Studies, Rue Dupanloup, Orléans, 45000, France

Sedda, D.; Laboratory of Molecular and Experimental Immunology and Neuro-genetics, UMR 7355, CNRS-University of Orleans, Le Studium Institute for Advanced Studies, Rue Dupanloup, Orléans, 45000, France

Nyangahu, D.; Institute of Infectious Disease and Molecular Medicine, Division of Immunology, University of Cape Town, Cape Town, 7925, South Africa

Jaspan, H.; Institute of Infectious Disease and Molecular Medicine, Division of Immunology, University of Cape Town, Cape Town, 7925, South Africa, Seattle Children's Research Institute, Departments of Paediatrics and Global Health, University of Washington, Seattle, WA, United States

Toellner, K.-M.; Institute of Immunology and Immunotherapy, School of Immunity and Infection, University of Birmingham, Birmingham, B15 2TT, United Kingdom

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Title :

Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

Publication date :

2019

Journal title :

Science Advances

eISSN :

2375-2548

Publisher :

American Association for the Advancement of Science

Volume :

Issue :

Peer reviewed :

Peer Reviewed verified by ORBi

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since 20 June 2019

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