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Is it possible to predict the odor of a molecule on the basis of its structure?

Genva, Manon; Kenne Kemene, Tierry; Deleu, Magali et al.

2019 • In International Journal of Molecular Sciences, 20 (12), p. 3018

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https://hdl.handle.net/2268/236996

DOI
10.3390/ijms20123018

PubMed
31226833

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Keywords :

olfaction; odor; sensory perception; flavor; volatile organic compounds; structure-function relationship; olfactory sense; odorant

Abstract :

[en] The olfactory sense is the dominant sensory perception for many animals. When Richard Axel and Linda Buck received in 2004 the Nobel Prize for discovering the G-protein coupled receptors role in olfactory cells, it highlighted the importance of olfaction to scientific community. Several theories tried to explain how cells are able to distinguish such a wide variety of odorant molecules in a complex context in which enantiomers can result in completely different perceptions and structurally different molecules in the same one. Moreover, sex, age, cultural origin and individual differences contribute to odor perception variations that complicate the picture. Recent advances in olfaction theory will be presented and future trends in human olfaction like structure-based odor prediction or artificial sniffing will be discussed at the frontiers of chemistry, physiology, neurobiology and machine learning.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Genva, Manon ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes

Kenne Kemene, Tierry ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes

Deleu, Magali ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes

Lins, Laurence ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes

Fauconnier, Marie-Laure ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes

Language :

English

Title :

Is it possible to predict the odor of a molecule on the basis of its structure?

Publication date :

20 June 2019

Journal title :

International Journal of Molecular Sciences

ISSN :

1661-6596

eISSN :

1422-0067

Publisher :

Multidisciplinary Digital Publishing Institute (MDPI), Switzerland

Volume :

20

Issue :

12

Pages :

art. 3018

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.mdpi.com/1422-0067/20/12/3018/htm

Name of the research project :

European Hub on New Challenges in the Field of Essentials Oils (EOHUB)

Funders :

EACEA - Agence exécutive européenne pour l’Education et la Culture

Available on ORBi :

since 18 June 2019

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