Article (Scientific journals)
HER2+ breast cancer treatment and cardiotoxicity: monitoring and management.
Jerusalem, Guy; Lancellotti, Patrizio; Kim, Sung-Bae
2019In Breast Cancer Research and Treatment
Peer Reviewed verified by ORBi
 

Files


Full Text
HER+ breast cancer treatment ... article GJ.pdf
Publisher postprint (736.39 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Anthracyclines; Breast neoplasms; Cardiotoxicity; Trastuzumab
Abstract :
[en] BACKGROUND: Breast cancer is a leading cause of death for women worldwide, with incidence increasing in lower-income countries. For patients with human epidermal growth factor receptor-2-positive (HER2+) breast cancer, widespread availability of several agents targeting the HER2 receptor has resulted in survival gains over the past decades. However, improved survival has resulted in an increased need for management and mitigation of adverse events associated with anticancer therapy. Cardiac adverse events such as decreased ejection fraction and heart failure have been of particular concern in patients with HER2+ breast cancer. Anti-HER2 agents and chemotherapies (specifically anthracyclines, which are frequently used to treat HER2+ disease) have been associated with cardiotoxicity. As increasing numbers of patients are living longer due to more effective therapy, a better understanding of both monitoring and management of cardiotoxicity is urgently needed. METHODS: A comprehensive review of the literature was conducted via PubMed in January 2018 for phase II and phase III trials of "trastuzumab", "lapatinib", "pertuzumab", "T-DM1", "neratinib", in "breast cancer". Literature was evaluated for content related to cardiac adverse events. FINDINGS: We describe the incidence of and proposed mechanisms for the cardiotoxicity of available HER2-targeted therapies. We summarize current and emerging practices in the management of cardiotoxicity and provide guidance for routine patient care in real-world practice using illustrative patient scenarios. CONCLUSIONS: The future of cardiotoxicity management in patients with HER2+ breast cancer is discussed, with a focus on novel techniques to improve cardiac outcomes, including new imaging modalities, biomarkers, interventional therapies, and ongoing trials.
Disciplines :
Oncology
Author, co-author :
Jerusalem, Guy  ;  Université de Liège - ULiège > Département des sciences cliniques > Oncologie
Lancellotti, Patrizio  ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Kim, Sung-Bae
Language :
English
Title :
HER2+ breast cancer treatment and cardiotoxicity: monitoring and management.
Publication date :
2019
Journal title :
Breast Cancer Research and Treatment
ISSN :
0167-6806
eISSN :
1573-7217
Publisher :
Kluwer Academic Publishers, Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Please find herewith the link for free full paper access : https://rdcu.be/bFHth
Available on ORBi :
since 12 June 2019

Statistics


Number of views
59 (12 by ULiège)
Number of downloads
4 (4 by ULiège)

Scopus citations®
 
79
Scopus citations®
without self-citations
79
OpenCitations
 
46

Bibliography


Similar publications



Contact ORBi