[en] Several lines of evidence suggest catecholamine overactivity (noradrenergic and/or dopaminergic) in mania. We studied the growth hormone (GH) response to clonidine (an alpha-adrenergic agonist) and apomorphine (a dopaminergic agonist) in seven inpatients meeting Research Diagnostic Criteria for mania. They had been completely drug free for at least 3 months before the neuroendocrine procedures and were age- and sex-matched to seven major depressive and seven minor depressive inpatients, drug free for at least 2 weeks. GH was assayed every 20 min for 40 min before and 120 min after either clonidine (0.15 mg i.v.) or apomorphine (0.5 mg s.c.), with an interval of at least 2 days between the tests. The three groups differed significantly in the GH peak response: after clonidine (mean +/- SD), 3.2 +/- 2.4 ng/ml in manics, 3.2 +/- 2.4 ng/ml in major depressives, and 13.2 +/- 8.7 ng/ml in minor depressives; after apomorphine, 10.5 +/- 7.4, 3.2 +/- 1.9, and 26.9 +/- 15.8, respectively. While there were significant differences between manics and minor depressives and between major and minor depressives after both clonidine and apomorphine, manics did not significantly differ from major depressives on either test. These results do not provide neuroendocrine support to the catecholaminergic hypothesis of manic disorders.
Disciplines :
Psychiatry
Author, co-author :
Ansseau, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
von Frenckell, Rémy ; Université de Liège - ULiège > Unité de Psychiatrie Biologique et de Psychopharmacologie
Cerfontaine, Jean-Luc; Université de Liège - ULiège > Service de Neuropsychiatrie
Papart, Patrick ; Université de Liège - ULiège > Département des sciences cliniques > Psycho. quantitative - Psychiatrie légale et sociale
Franck, Georges ; Université de Liège - ULiège > Relations académiques et scientifiques
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Bibliography
Ansseau, Scheyvaerts, Doumont, Poirrier, Legros, Franck (1984) Concurrent use of REM latency, dexamethasone suppression test, clonidine, and apomorphine tests as biological markers of endogenous depression: A pilot study. Psychiatry Research 12:261.
Ansseau, von Frenckell, Franck, Timsit-Berthier, Geenen, Legros (1986) Blunted growth hormone responses to clonidine and apomorphine challenges in endogenous depression. Biological Psychiatry 1985 , C. Shagass, R.C. Josiassen, W.H. Bridger, K.S. Weiss, D. Stoff, G.M. Simpson, Elsevier, New York; 793.
Brodie, Murphy, Goodwin, Bunney (1971) Catecholamines and mania—The effects of alpha-methyl-paratyrosine on manic behavior and catecholamine metabolism. Clinical Pharmacology and Therapeutics 12:218.
Bunney, Post, Andersen, Kopanda (1977) A neuronal receptor sensitivity mechanism in affective illness (a review of evidence). Communications in Psychopharmacology 1:393.
Casper, Davis, Pandey, Garver, Dekirmenjian (1977) Neuroendocrine and amine studies in affective illness. Psychoneuroendocrinology 2:105.
Charney, Heninger, Sternberg, Hafstad, Giddings, Landis (1982) Adrenergic receptor sensitivity in depression: Effects of clonidine in depressed patients and healthy subjects. Archives of General Psychiatry 39:290.
Checkley (1980) Neuroendocrine tests of monoamine function in man: A review of basic theory and its application to the study of depressive illness. Psychological Medicine 10:35.
Checkley, Corn, Glass, Thompson (1984) Central alpha adrenoceptor function following chronic desipramine treatment in depressed patients and normal subjects. Abstracts of the 14th CINP, Florence; .
Checkley, Glass, Thompson, Corn, Robinson (1984) The GH response to clonidine in endogenous as compared with reactive depression. Psychological Medicine 14:773.
Checkley, Slade, Shur (1981) Growth hormone and other responses to clonidine in patients with endogenous depression. British Journal of Psychiatry 138:51.
Cookson (1985) The neuroendocrinology of mania. Journal of Affective Disorders 8:223.
Cookson, Silverstone, Wells (1981) A double-blind comparative clinical trial of pimozide and chlorpromazine in mania—A test of the dopamine hypothesis. Acta Psychiatrica Scandinavica 64:381.
Cookson, Silverstone, Williams, Besser (1985) Plasma cortisol levels in mania: Associated clinical ratings and changes during treatment with haloperidol. British Journal of Psychiatry 146:498.
Corn, Hale, Thompson, Bridges, Checkley (1984) A comparison of the growth hormone responses to clonidine and apomorphine in the same patients with endogenous depression. British Journal of Psychiatry 144:636.
Ettigi, Lal, Martin, Friesen (1975) Effect of sex, oral contraceptives, and glucose loading on apomorphine-induced growth hormone secretion. Journal of Clinical Endocrinology and Metabolism 40:1094.
Franchimont, Salmon (1962) Dosage immunologique de la somatotrophine humaine. Annales d'Endocrinologie 23:556.
Frazer (1975) Adrenergic responses to depression: Implications for a receptor defect. The Psychobiology of Depression, J. Mendels, Spectrum Publications, New York; .
Garver, Pandey, Dekirmenjian, Deleon-Jones (1975) Growth hormone and catecholamines in affective disease. American Journal of Psychiatry 132:1149.
Garver, Pandey, Hengeveld, Davis (1981) Growth hormone response and central aminergic systems in affective diseases. Psychopharmacology Bulletin 13(1):61.
Gerner, Post, Bunney (1976) A dopaminergic mechanism in mania. American Journal of Psychiatry 133:1177.
Gold, Goodwin, Wehr, Rebar, Sack (1976) Growth hormone and prolactin response to levodopa in affective illness. Lancet 2:1308.
Halbreich, Kang, Asnis (1986) Some factors influencing the growth hormone response to desmethylimipramine and other pharmacological stimuli. Biological Psychiatry 1985 , C. Shagass, R.C. Josiassen, W.H. Bridger, K.S. Weiss, D. Stoff, G.M. Simpson, Elsevier, New York; 785.
Hirschowitz, Zemlan, Hitzemann, Fleischmann, Garver (1986) Growth hormone response to apomorphine and diagnosis: A comparison of three diagnostic systems. Biological Psychiatry 21:445.
Hoehe, Valido, Matussek (1986) Growth hormone response to clonidine in endogenous depressive patients: Evidence for a trait marker in depression. Biological Psychiatry 1985 , C. Shagass, R.C. Josiassen, W.H. Bridger, K.S. Weiss, D. Stoff, G.M. Simpson, Elsevier, New York; 862.
Jimerson, Cutler, Post, Rey, Gold, Brown, Bunney (1984) Neuroendocrine responses to apomorphine in depressed patients and healthy control subjects. Psychiatry Research 13:1.
Jouvent, Lecrubier, Puech, Simon, Widlocher (1980) Antimanic effect of clonidine. American Journal of Psychiatry 137:1275.
Lal, Etienne, Thavundayil, Nair, Collier, Rastogi, Guyda, Schwartz (1981) Effects of choline on central dopaminergic function in normal subjects. Journal of Neural Transmission 50:29.
Langer, Sachar (1977) Diet and growth hormone response in affective illness. Lancet 1:652.
Linkowski, Brauman, Mendlewicz (1983) Prolactin and growth hormone response to levodopa in affective illness. Neuropsychobiology 9:108.
Maany, Mendels, Frazer, Brunswick (1979) A study of growth hormone release in depression. Neuropsychobiology 5:282.
Maggi, U'Prichard, Enna (1980) Beta-adrenergic regulation of alpha-2-adrenergic receptors in the central nervous system. Science 207:645.
Matussek, Ackenheil, Hippius, Müller, Schröder, Schultes, Wasilewski (1980) Effect of clonidine on growth hormone release in psychiatric patients and controls. Psychiatry Research 2:25.
Meltzer, Kolakowska, Fang, Fogg, Robertson, Lewine, Strahilevitz, Busch (1984) Growth hormone and prolactin response to apomorphine in schizophrenia and the major affective disorders. Archives of General Psychiatry 41:512.
Mendlewicz, Linkowski, Brauman (1977) Growth hormone and prolactin response to levodopa in affective illness. Lancet 1:652.
Murphy (1972) l-DOPA—Behavioral activation and psychopathology. Neurotransmitters , I.J. Kopin, Research Publications—Association of Research in Nervous and Mental Disease; 50:472.
Nolen (1983) Dopamine and mania—The effects of trans- and cis-clopenthixol in a double-blind pilot study. Journal of Affective Disorders 5:91.
Post (1980) Biochemical theories of mania. Mania: An Evolving Concept, R.H. Belmaker, H.M. van Praag, Spectrum Publications, New York; .
Sachar, Altman, Gruen, Glassman, Halpern, Sassin (1975) Human growth hormone response to levodopa: Relation to menopause, depression and plasma dopa concentration. Archives of General Psychiatry 32:502.
Sachar, Frantz, Altman, Sassin (1973) Growth hormone and prolactin in unipolar and bipolar depressed patients: Responses to hypoglycemia and l-DOPA. American Journal of Psychiatry 130:1362.
Siever, Coccaro, Adan, Benjamin, Davis (1986) The growth hormone response to clonidine in acute and remitted affective disorder patients. Biological Psychiatry 1985 , C. Shagass, R.C. Josiassen, W.H. Bridger, K.S. Weiss, D. Stoff, G.M. Simpson, Elsevier, New York; 791.
Siever, Uhde (1984) New studies and perspectives on the noradrenergic receptor system in depression: Effects of the alpha-2-adrenergic agonist clonidine. Biological Psychiatry 19:131.
Siever, Uhde, Silberman, Jimerson, Aloi, Post, Murphy (1982) Growth hormone response to clonidine as a probe of noradrenergic receptor responsiveness in affective disorder patients and controls. Psychiatry Research 6:171.
Silverstone (1984) Response to bromocriptine distinguishes bipolar from unipolar depression. Lancet 1:903.
Silverstone (1985) Dopamine in manic depressive illness: A pharmacological synthesis. Journal of Affective Disorders 8:225.
Spitzer, Endicott, Robins (1978) Research Diagnostic Criteria: Rationale and reliability. Archives of General Psychiatry 35:773.
Svensson, Bunney, Aghajanian (1975) Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine. Brain Research 92:291.
Timsit-Berthier, Mantanus, Marissiaux, Ansseau, Doumont, Geenen, Legros (1986) CNV and dopamine receptor reactivity: Correlations with the apomorphine test. Cerebral Psychophysiology: Studies of Event-Related Potentials , W.C. McCallum, R. Zappoli, F. Denoth, Elsevier Science Publishers, Amsterdam; 403.
Watanabe, Manome, Kaneko, Numata, Hoshino, Kanno, Kumashiro (1985) Human growth hormone response to clonidine in patients with affective disorder. Abstracts of the 16th Congress of the International Society of Psychoneuroendocrinology, Kyoto; .
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