Diagnostic performance of basal free cortisol/18-hydroxy-11-deoxy-corticosterone (18-OH-DOC) ratio in endogenous depression: comparison with the dexamethasone suppression test

Demey-Ponsart, Edmée; Ansseau, Marc; Sulon, José; von Frenckell, Rémy; Cerfontaine, Jean-Luc; Papart, Patrick; Franck, Georges; Geenen, Vincent; Legros, Jean-Jacques

doi:10.1016/0006-3223(87)90004-7

Article (Scientific journals)

Diagnostic performance of basal free cortisol/18-hydroxy-11-deoxy-corticosterone (18-OH-DOC) ratio in endogenous depression: comparison with the dexamethasone suppression test

Demey-Ponsart, Edmée; Ansseau, Marc; Sulon, José et al.

1987 • In Biological Psychiatry, 22 (8), p. 947-956

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/23679

DOI
10.1016/0006-3223(87)90004-7

PubMed
3607136

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Keywords :

Depressive Disorder; Hydrocortisone

Abstract :

[en] We assessed the 8:00 AM ratio of free cortisol/18-hydroxy-11-deoxycorticosterone (18-OH-DOC) in 56 endogenous depressive inpatients and in 22 normal volunteers. A ratio higher than 40 was associated with a diagnostic sensitivity for endogenous depression of 75%, a specificity of 95.5%, and a diagnostic confidence of 97.7%. These diagnostic results were at least equivalent to the Dexamethasone Suppression Test (DST) using a cortisol cut-off limit of 5 micrograms/dl. This may thus represent a simpler procedure than the DST in the diagnostic analysis of endogenous depression.

Disciplines :

Psychiatry

Author, co-author :

Demey-Ponsart, Edmée; Université de Liège - ULiège > Department of Clinical and Medical Pathology

Ansseau, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale

Sulon, José; Université de Liège - ULiège

von Frenckell, Rémy ; Université de Liège - ULiège > Unité de Psychiatrie Biologique et de Psychopharmacologie

Cerfontaine, Jean-Luc; Université de Liège - ULiège > Service de Neuropsychiatrie

Papart, Patrick ; Université de Liège - ULiège > Département des sciences cliniques > Psycho. quantitative - Psychiatrie légale et sociale

Franck, Georges ; Université de Liège - ULiège > Relations académiques et scientifiques

Geenen, Vincent ; Université de Liège - ULiège > Centre d'immunologie - Embryologie

Legros, Jean-Jacques ; Université de Liège - ULiège > Endocrinologie clinique

Language :

English

Title :

Diagnostic performance of basal free cortisol/18-hydroxy-11-deoxy-corticosterone (18-OH-DOC) ratio in endogenous depression: comparison with the dexamethasone suppression test

Publication date :

1987

Journal title :

Biological Psychiatry

ISSN :

0006-3223

Publisher :

Elsevier, New York, United States - New York

Volume :

Issue :

Pages :

947-956

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 24 September 2009

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Bibliography

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