Diagnostic performance of basal free cortisol/18-hydroxy-11-deoxy-corticosterone (18-OH-DOC) ratio in endogenous depression: comparison with the dexamethasone suppression test
[en] We assessed the 8:00 AM ratio of free cortisol/18-hydroxy-11-deoxycorticosterone (18-OH-DOC) in 56 endogenous depressive inpatients and in 22 normal volunteers. A ratio higher than 40 was associated with a diagnostic sensitivity for endogenous depression of 75%, a specificity of 95.5%, and a diagnostic confidence of 97.7%. These diagnostic results were at least equivalent to the Dexamethasone Suppression Test (DST) using a cortisol cut-off limit of 5 micrograms/dl. This may thus represent a simpler procedure than the DST in the diagnostic analysis of endogenous depression.
Disciplines :
Psychiatry
Author, co-author :
Demey-Ponsart, Edmée; Université de Liège - ULiège > Department of Clinical and Medical Pathology
Ansseau, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Sulon, José; Université de Liège - ULiège
von Frenckell, Rémy ; Université de Liège - ULiège > Unité de Psychiatrie Biologique et de Psychopharmacologie
Cerfontaine, Jean-Luc; Université de Liège - ULiège > Service de Neuropsychiatrie
Papart, Patrick ; Université de Liège - ULiège > Département des sciences cliniques > Psycho. quantitative - Psychiatrie légale et sociale
Franck, Georges ; Université de Liège - ULiège > Relations académiques et scientifiques
Geenen, Vincent ; Université de Liège - ULiège > Centre d'immunologie - Embryologie
Diagnostic performance of basal free cortisol/18-hydroxy-11-deoxy-corticosterone (18-OH-DOC) ratio in endogenous depression: comparison with the dexamethasone suppression test
Ansseau, Sulon, Doumont, Cerfontaine, Legros, Sodoyez, Demey-Ponsart (1984) Use of saliva Cortisol in the Dexamethasone Suppression Test. Psychiatry Res 13:203-211.
Ansseau, Simon, Sulon, Demey-Ponsart, von Frenckell, Geenen, Legros, Van Cauwenberge, Franck (1985) 18-Hydroxy-11-deoxycorticosterone (18-OH-DOC) and Dexamethasone Suppression Test. Paper presented at the IVth World Congress of Biological Psychiatry, Philadelphia, September 1985; .
Carroll, Feinberg, Greden, Tarika, Albala, Hasket, James, Kronfol, Lohr, Steiner, De Vigne, Young (1981) A specific laboratory test for the diagnosis of melancholia. Arch Gen Psychiatry 38:15-22.
Charles, Ansseau, Sulon, Demey-Ponsart, Meunier, Wilmotte, Legros (1986) Free cortisol and the Dexamethasone Suppression Test. Biol Psychiatry 21:549-552.
Demey-Ponsart, Foidart, Hendrickx, Sodoyez (1977) Effect of serum dilution on binding of cortisol to thermolabile and thermostable serum proteins. J Steroid Biochem 8:1091-1095.
Fang, Tricou, Robertson, Meltzer (1981) Plasma ACTH and cortisol levels in depressed patients: Relation to dexamethasone suppression test. Life Sci 29:931-938.
Gower, Cooke (1983) Regulation of steroid transforming enzymes by endogenous steroids. J Steroid Biochem 19:1527-1556.
Hirschfeld, Koslow, Kupfer (1983) The clinical utility of the Dexamethasone Suppression Test in psychiatry: Summary of a National Institute of Mental Health workshop. JAMA 250:2172-2174.
Holsboer (1983) The Dexamethasone Suppression Test in depressed patients: Clinical and biochemical aspects. J Steroid Biochem 19:251-257.
Holsboer, Winter, Dorr, Sippell (1982) Dexamethasone Suppression Test in female patients with endogenous depression: Determination of plasma corticosterone, 11-deoxycorticosterone, 11-deoxycortisol, cortisol and cortisone. Psychoneuroendocrinology 7:329-338.
Holsboer, Doerr, Gerken, Muller, Sippell (1984) Cortisol, 11-deoxycortisol and ACTH concentrations after dexamethasone in depressed patients and healthy volunteers. Psychiatry Res 11:15-23.
Kalin, Weiler, Shelton (1982) Plasma ACTH and cortisol concentrations before and after dexamethasone. Psychiatry Res 7:87-92.
Krieger, Allen (1975) Relationship of bioassayable and immunoassayable plasma ACTH and cortisol concentrations in normal subjects and in patients with Cushing's disease. J Clin Endocrinol Metab 40:675-687.
May, Lewis, Horth (1979) Radioimmunoassay of plasma 18 hydroxy-11-deoxycorticosterone and its response to ACTH. Clin Endocrinol 11:399-412.
Palem-Vliers, Sulon (1978) Estimation of 18-hydroxy-11 -deoxycorticosterone in human plasma and urine including a comparison of various techniques. J Steroid Biochem 9:239-243.
Pfohl, Sherman, Schlechte, Winokur (1985) Differences in plasma ACTH and cortisol between depressed patients and normal controls. Biol Psychiatry 20:1055-1072.
Reus, Joseph, Dallman (1982) ACTH levels after the Dexamethasone Suppression Test in depression. N Engl J Med 306:283-284.
Roy, Ramirez, Ulick (1976) Structure and mechanism of formation of the two forms of 18-hydroxy-11-deoxycorticosterone. J Steroid Biochem 7:81-87.
Spitzer, Endicott, Robins (1978) Research Diagnostic Criteria: Rationale and reliability. Arch Gen Psychiatry 35:773-782.
Sulon, Sparano (1978) A non-chromatographic radioimmunoassay of 18-hydroxy-l1-deoxycorticosterone in human plasma. J Steroid Biochem 9:253-256.
Sulon, Demey-Ponsart, Bauduin, Sodoyez (1978) Radioimmunoassay of corticosterone, cortisone and Cortisol. Their application to human cord and maternal plasma. J Steroid Biochem 9:671-676.
Vecchio (1966) Predictive value of a single diagnostic test in an unselected population. N Engl J Med 274:1171-1173.
Yerevanian, Woolf (1983) Plasma ACTH levels in primary depression Relationship to the 24-hour Dexamethasone Suppression Test. Psychiatry Research 12:155-160.
