Subsaturation of the NMDAR glycine site allows the regulation of bursting activity in juvenile rat nigral dopamine neurons

Destreel, Geoffrey; Seutin, Vincent; Engel, Dominique

doi:10.1111/ejn.14491

Article (Scientific journals)

Subsaturation of the NMDAR glycine site allows the regulation of bursting activity in juvenile rat nigral dopamine neurons

Destreel, Geoffrey; Seutin, Vincent; Engel, Dominique

2019 • In European Journal of Neuroscience, 50 (9), p. 3454-3471

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https://hdl.handle.net/2268/236774

DOI
10.1111/ejn.14491

PubMed
31206829

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Keywords :

dopamine neuron; substantia nigra; NMDA receptors

Abstract :

[en] The activation of N-methyl-D-aspartate receptors (NMDARs) in substantia nigra pars compacta (SNc) dopamine (DA) cells is central to generate the bursting activity, a phasic signal linked to DA related behaviors via the change in postsynaptic DA release. NMDARs are recruited during excitatory synaptic transmission by glutamate release but the glycine site level of occupancy of these receptors during basal action potential-dependent activity is not known for SNc DA neurons. We explored NMDARdependent signals during exogenous applications of co-agonists in midbrain slices from juvenile rats. We found that both glycine and D-serine strengthened the NMDAR-dependent component of excitatory postsynaptic currents (EPSCs) in a concentration-dependent manner. EPSCs were also increased by endogenous glycine via the blockade of the glycine transport. The glycine site of NMDARs contributing to synaptic transmission is therefore subsaturated. The behaviorally relevant burst firing was more sensitive to exogenous D-serine and endogenous glycine than to exogenous glycine. The mechanisms regulating the availability of the co-agonists exert consequently a critical influence on the excitability of DA neurons via NMDARs. The modulation of the phasic firing in DA neurons by ambient NMDAR co-agonists may be important for nigral information processing and downstream motor-related behavior.

Research Center/Unit :

Giga-Neurosciences - ULiège

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Destreel, Geoffrey ; Université de Liège - ULiège > Neurosciences-Neurophysiology

Seutin, Vincent ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie

Engel, Dominique ; Université de Liège - ULiège > Neurosciences-Neurophysiology

Language :

English

Title :

Subsaturation of the NMDAR glycine site allows the regulation of bursting activity in juvenile rat nigral dopamine neurons

Alternative titles :

[en] La sous-saturation du site de la glycine des récepteurs NMDA permet la régulation de l'activité en bouffée dans les neurones à dopamine de la substance noire compacte de rat juvénile

Publication date :

10 June 2019

Journal title :

European Journal of Neuroscience

ISSN :

0953-816X

eISSN :

1460-9568

Publisher :

Blackwell, Oxford, United Kingdom

Volume :

Issue :

Pages :

3454-3471

Peer reviewed :

Peer Reviewed verified by ORBi

Name of the research project :

Physiology of dopaminergic neurons

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 12 June 2019

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