Inhibitory influence of oxytocin infusion on contingent negative variation and some memory tasks in normal men

[en] A double-blind study combining electrophysiological and psychometrical approaches was carried out to investigate the central effects of an intravenous oxytocin (OT) infusion in normal men. Contingent negative variation (CNV) was selected as the measure of central cognitive evoked potential, and the psychometric tests measured mood, vigilance and memory. OT infusion induced a significant decrease of CNV amplitude and an increase of post-imperative positive potentials in vertex derivations. A similar effect was still evidenced one week after treatment in frontal derivations, suggesting a long time effect of OT on human brain. No significant influence of OT on mood or vigilance tests was apparent; only one item of a memory test revealed a significant impairment of some mnesic performances. These observations provide new electrophysiological arguments supporting a central action of peripheral OT administration in man.

Disciplines :

Neurology

Author, co-author :

Geenen, Vincent ; Université de Liège - ULiège > Centre d'immunologie - Embryologie

Adam, Francine; Université de Liège - ULiège > Psychoneuroendocrinologie

Baro, Vincent; Université de Liège - ULiège > Psychiatrie & psychopharmacologie

Mantanus, Huguette; Université de Liège - ULiège > Psychoneuroendocrinologie

Ansseau, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale

Timsit-Berthier, Martine ; Université de Liège - ULiège > Psychoneuroendocrinologie

Legros, Jean-Jacques ; Université de Liège - ULiège > Endocrinologie clinique

Language :

English

Title :

Inhibitory influence of oxytocin infusion on contingent negative variation and some memory tasks in normal men

Publication date :

1988

Journal title :

Psychoneuroendocrinology

ISSN :

0306-4530

eISSN :

1873-3360

Publisher :

Pergamon Press - An Imprint of Elsevier Science, Oxford, United Kingdom

Volume :

Issue :

Pages :

367-375

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 24 September 2009

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