Article (Scientific journals)
Diabetes Research & Clinical Practice Series : Implications of the recent CVOTs in Type 2 Diabetes: Impact on guidelines: the endocrinologist point of view.
Scheen, André
2019In Diabetes Research and Clinical Practice
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Keywords :
Cardiovascular disease; Chronic kidney disease; GLP-1 receptor agonist; Guidelines; Heart failure; SGLT2 inhibitor; Type 2 diabetes
Abstract :
[en] The management of type 2 diabetes mellitus (T2DM) essentially consists in controlling hyperglycaemia, together with other vascular risk factors, in order to reduce the incidence and severity of diabetic complications. Whereas glucose control using classical glucose-lowering agents (except perhaps metformin) largely fails to reduce cardiovascular disease (CVD), two new pharmacological classes, glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter type 2 inhibitors (SGLT2is), have proven their ability to reduce major cardiovascular events in patients with established CVD. Furthermore, SGLT2is reduced the risk of hospitalisation for heart failure and the progression of renal disease. According to the 2018 ADA-EASD consensus report, the choice of a second agent to be added to metformin should now be driven by the presence or not of atherosclerotic CVD, heart failure or renal disease, all conditions that should promote the use of a SGLT2i or a GLP-1 RA with proven efficacy. Thus endocrinologists have to face a new paradigm in the management of T2DM, with a shift from a primary objective of glucose control without inducing hypoglycaemia and weight gain to a goal of cardiovascular and renal protection, largely independent of glucose control. Of note, however, the latter remains crucial to reduce the risk of microangiopathy.
Disciplines :
Endocrinology, metabolism & nutrition
Cardiovascular & respiratory systems
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Language :
English
Title :
Diabetes Research & Clinical Practice Series : Implications of the recent CVOTs in Type 2 Diabetes: Impact on guidelines: the endocrinologist point of view.
Publication date :
2019
Journal title :
Diabetes Research and Clinical Practice
ISSN :
0168-8227
eISSN :
1872-8227
Publisher :
Elsevier, Amsterdam, Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2019. Published by Elsevier B.V.
Available on ORBi :
since 03 June 2019

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