Article (Scientific journals)
Determining clinically important differences in health-related quality of life in older patients with cancer undergoing chemotherapy or surgery
Quinten, C.; Kenis, C.; Decoster, L. et al.
2019In Quality of Life Research, 28 (3), p. 663-676
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Keywords :
Cancer; Elderly patients with cancer; Geriatric assessment; Minimal important differences; Quality of life
Abstract :
[en] Purpose: Using the EORTC Global Health Status (GHS) scale, we aimed to determine minimal clinically important differences (MCID) in health-related quality of life (HRQOL) changes for older cancer patients with a geriatric risk profile, as defined by the geriatric 8 (G8) health screening tool, undergoing treatment. Simultaneously, we assessed baseline patient characteristics prognostic for HRQOL changes. Methods: Our analysis included 1424 (G8 ≤ 14) older patients with cancer scheduled to receive chemotherapy (n = 683) or surgery (n = 741). Anchor-based methods, linking the GHS score to clinical indicators, were used to determine MCID between baseline and follow-up at 3 months. A threshold of 0.2 standard deviation (SD) was used to exclude MCID estimates too small for interpretation. Logistic regressions analysed baseline patient characteristics prognostic for HRQOL changes. Results: The 15-item Geriatric Depression Scale (GDS15), Visual Analogue Scale (VAS) for Fatigue and ECOG Performance Status (PS) were selected as clinical anchors. In the surgery group, MCID estimates for improvement and deterioration were ECOG PS (5*, 11*), GDS15 (5*, 2) and VAS Fatigue (3, 9*). In the chemotherapy group, MCID estimates for improvement and deterioration were ECOG PS (8*, 7*), GDS15 (5, 4) and VAS Fatigue (5, 5*). Estimates with * were > 0.2 SD threshold. Patients experiencing pain or malnutrition (surgery group) or fatigue (chemotherapy group) at baseline showed a significantly stable or improved HRQOL (p < 0.05) after their treatment. Conclusion: The reported MCID for improvement and deterioration depended on the anchor used and treatment received. The estimates can be used to evaluate significant changes in HRQOL and to determine sample sizes in clinical trials. © 2018, Springer Nature Switzerland AG.
Disciplines :
Oncology
Author, co-author :
Quinten, C.;  Laboratory of Experimental Oncology (LEO), Department of Oncology, KU Leuven, Leuven, Belgium, Department of General Medical Oncology and Geriatric Medicine, University Hospitals Leuven, Herestraat 49, Leuven, 3000, Belgium
Kenis, C.;  Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium, Department of Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium
Decoster, L.;  Department of Medical Oncology, Oncologisch Centrum, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
Debruyne, P. R.;  Cancer Centre, General Hospital Groeninge, Kortrijk, Belgium & Positive Ageing Research Institute (PARI), Anglia Ruskin University, Chelmsford, United Kingdom
De Groof, I.;  Department of Geriatric Medicine, Iridium Cancer Network Antwerp, St. Augustinus, Wilrijk, Belgium
Focan, C.;  Department of Oncology, Clinique Saint-Joseph, CHC-Liège Hospital Group, Liege, Belgium
Cornelis, F.;  Department of Medical Oncology, Cliniques Universitaires Saint-Luc, UCL, Brussels, Belgium
Verschaeve, V.;  Department of Medical Oncology, GHDC Grand Hôpital de Charleroi, Charleroi, Belgium
Bachmann, C.;  Department of Geriatric Medicine, AZ Sint-Lucas, Ghent, Belgium
Bron, D.;  Department of Hematology, ULB Institut Jules Bordet, Brussels, Belgium
Luce, S.;  Department Medical Oncology, University Hospital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium
Debugne, G.;  Department of Geriatric Medicine, Centre Hospitalier de Mouscron, Mouscron, Belgium
Van den Bulck, H.;  Department of Medical Oncology, Imelda Hospital, Bonheiden, Belgium
Goeminne, J. C.;  Department of Medical Oncology, CHU-UCL-Namur, site Sainte-Elisabeth, Namur, Belgium
Baitar, A.;  Department of Medical Oncology, ZNA Middelheim, Antwerp, Belgium
Geboers, K.;  Centre for Oncology and Hematology, AZ Turnhout, Turnhout, Belgium
Petit, B.;  Department of Medical Oncology, Centre Hospitalier Jolimon, La Louvière, Belgium
Langenaeken, C.;  Department of Medical Oncology, Iridium Cancer Network Antwerp, AZ Klina, Brasschaat, Belgium
Van Rijswijk, R.;  Department of Medical Oncology, ZNA Stuivenberg, Antwerp, Belgium
Specenier, P.;  Department of Medical Oncology, University Hospital Antwerp, Antwerp, Belgium
JERUSALEM, Guy  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service d'oncologie médicale
Praet, J. P.;  Department of Geriatric Medicine, CHU St-Pierre, Free Universities Brussels, Brussels, Belgium
Vandenborre, K.;  Department of Medical Oncology, AZ Vesalius, Tongeren, Belgium
Lycke, M.;  Cancer Centre, General Hospital Groeninge, Kortrijk, Belgium & Positive Ageing Research Institute (PARI), Anglia Ruskin University, Chelmsford, United Kingdom
Flamaing, J.;  Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium, Department of Chronic Diseases, Metabolism and Ageing – CHROMETA, KU Leuven, Leuven, Belgium
Milisen, K.;  Department of Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium, Department of Public Health and Primary Care, Academic Centre for Nursing and Midwifery, KU Leuven, Leuven, Belgium
Lobelle, J. P.;  Beernem, Belgium
Wildiers, H.;  Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium, Department of Oncology, KU Leuven, Leuven, Belgium
More authors (18 more) Less
Language :
English
Title :
Determining clinically important differences in health-related quality of life in older patients with cancer undergoing chemotherapy or surgery
Publication date :
2019
Journal title :
Quality of Life Research
ISSN :
0962-9343
eISSN :
1573-2649
Publisher :
Springer International Publishing
Volume :
28
Issue :
3
Pages :
663-676
Peer reviewed :
Peer Reviewed verified by ORBi
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