Health related quality of life in older patients with solid tumors and prognostic factors for decline

[en] Objectives: This study aims to investigate health-related quality of life (HRQOL) at baseline and at follow-up in older patients with cancer and to determine prognostic factors for HRQOL decline. Methods: A prospective Belgian multicentre (n = 22) study was performed. Patients ≥70 years with a malignant tumor and abnormal G8 (≤14/17) screening tool were included. Patients underwent geriatric assessment (GA) and HRQOL evaluation with follow up at three months. Uni- and multivariate regression models were performed to determine factors associated (p <.05) with baseline HRQOL and HRQOL decline at follow-up. Results: Results reflect data collected from 3673 patients. A multivariate analysis showed that younger patients, and those with poor Eastern Cooperative Oncology Group – Performance Status (ECOG-PS), specific tumor types (gastrointestinal, gynaecological and thorax) and higher stage had lower baseline HRQOL. In addition worse functional status and presence of pain, fatigue, depression and malnutrition were associated with lower baseline HRQOL. During treatment (n = 2972), improvement in HRQOL was observed in 1037 patients (35%) and a decline in 838 patients (28.2%). In multivariate analysis, stage and presence of baseline comorbidities, pain, fatigue or malnutrition were associated with HRQOL evolution. Conclusion: Baseline HRQOL in older patients with cancer and an abnormal G8 depends on tumor and age related parameters. During follow-up, HRQOL improved in one third of patients, indicating that they may benefit from cancer treatment while one quarter demonstrated a HRQOL decline for which prognostic factors were identified. © 2019 Elsevier Inc.

Disciplines :

Oncology

Author, co-author :

Decoster, L.; Department of Medical Oncology, Oncologisch Centrum, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium

Quinten, C.; Laboratory of Experimental Oncology (LEO), Department of Oncology, Leuven, KU, Belgium

Kenis, C.; Department of General Medical Oncology and Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium

Flamaing, J.; Department of Geriatric Medicine, University Hospitals Leuven and Department of Chronic Diseases, Metabolism and Ageing – CHROMETA, KU Leuven, Leuven, Belgium

Debruyne, P. R.; Cancer Centre, General Hospital Groeninge, Kortrijk, Belgium & Positive Ageing Research Institute (PARI), Anglia Ruskin University, Chelmsford, United Kingdom

De Groof, I.; Department of Geriatric Medicine, Iridium Cancer Network Antwerp, St. Augustinus, Wilrijk, Belgium

Focan, C.; Department of Oncology, Clinique Saint-Joseph, CHC-Liège Hospital Group, Liège, Belgium

Cornelis, F.; Department of Medical Oncology, Cliniques Universitaires Saint-Luc, UCL, Brussels, Belgium

Verschaeve, V.; Department of Medical Oncology, GHDC Grand Hôpital de Charleroi, Charleroi, Belgium

Bachmann, C.; Department of Geriatric Medicine, AZ Sint-Lucas, Gent, Belgium

More authors (18 more)

Language :

English

Title :

Health related quality of life in older patients with solid tumors and prognostic factors for decline

Publication date :

2019

Journal title :

Journal of Geriatric Oncology

ISSN :

1879-4068

eISSN :

1879-4076

Publisher :

Elsevier Ltd

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 29 May 2019

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