Article (Scientific journals)
Health related quality of life in older patients with solid tumors and prognostic factors for decline
Decoster, L.; Quinten, C.; Kenis, C. et al.
2019In Journal of Geriatric Oncology
Peer Reviewed verified by ORBi
 

Files


Full Text
Health related quality of life ... article GJ.pdf
Publisher postprint (463.16 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Cancer; Geriatric domains; Health-related quality of life; Older patients; Prognostic factors
Abstract :
[en] Objectives: This study aims to investigate health-related quality of life (HRQOL) at baseline and at follow-up in older patients with cancer and to determine prognostic factors for HRQOL decline. Methods: A prospective Belgian multicentre (n = 22) study was performed. Patients ≥70 years with a malignant tumor and abnormal G8 (≤14/17) screening tool were included. Patients underwent geriatric assessment (GA) and HRQOL evaluation with follow up at three months. Uni- and multivariate regression models were performed to determine factors associated (p <.05) with baseline HRQOL and HRQOL decline at follow-up. Results: Results reflect data collected from 3673 patients. A multivariate analysis showed that younger patients, and those with poor Eastern Cooperative Oncology Group – Performance Status (ECOG-PS), specific tumor types (gastrointestinal, gynaecological and thorax) and higher stage had lower baseline HRQOL. In addition worse functional status and presence of pain, fatigue, depression and malnutrition were associated with lower baseline HRQOL. During treatment (n = 2972), improvement in HRQOL was observed in 1037 patients (35%) and a decline in 838 patients (28.2%). In multivariate analysis, stage and presence of baseline comorbidities, pain, fatigue or malnutrition were associated with HRQOL evolution. Conclusion: Baseline HRQOL in older patients with cancer and an abnormal G8 depends on tumor and age related parameters. During follow-up, HRQOL improved in one third of patients, indicating that they may benefit from cancer treatment while one quarter demonstrated a HRQOL decline for which prognostic factors were identified. © 2019 Elsevier Inc.
Disciplines :
Oncology
Author, co-author :
Decoster, L.;  Department of Medical Oncology, Oncologisch Centrum, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
Quinten, C.;  Laboratory of Experimental Oncology (LEO), Department of Oncology, Leuven, KU, Belgium
Kenis, C.;  Department of General Medical Oncology and Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium
Flamaing, J.;  Department of Geriatric Medicine, University Hospitals Leuven and Department of Chronic Diseases, Metabolism and Ageing – CHROMETA, KU Leuven, Leuven, Belgium
Debruyne, P. R.;  Cancer Centre, General Hospital Groeninge, Kortrijk, Belgium & Positive Ageing Research Institute (PARI), Anglia Ruskin University, Chelmsford, United Kingdom
De Groof, I.;  Department of Geriatric Medicine, Iridium Cancer Network Antwerp, St. Augustinus, Wilrijk, Belgium
Focan, C.;  Department of Oncology, Clinique Saint-Joseph, CHC-Liège Hospital Group, Liège, Belgium
Cornelis, F.;  Department of Medical Oncology, Cliniques Universitaires Saint-Luc, UCL, Brussels, Belgium
Verschaeve, V.;  Department of Medical Oncology, GHDC Grand Hôpital de Charleroi, Charleroi, Belgium
Bachmann, C.;  Department of Geriatric Medicine, AZ Sint-Lucas, Gent, Belgium
Bron, D.;  Department of Hematology, ULB Institut Jules Bordet, Brussels, Belgium
Luce, S.;  Department Medical Oncology, University Hospital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium
Debugne, G.;  Department of Geriatric Medicine, Centre Hospitalier de Mouscron, Mouscron, Belgium
Van den Bulck, H;  Imelda Hospital, Bonheiden, Belgium > Department of Medical Oncology
Goeminne, J.-C.;  Department of Medical Oncology, CHU-UCL-Namur, Site Sainte-Elisabeth, Namur, Belgium
Baitar, A.;  Department of Medical Oncology, ZNA Middelheim, Antwerp, Belgium
Geboers, K.;  Centre for Oncology and Hematology, AZ Turnhout, Turnhout, Belgium
Petit, B.;  Department of Medical Oncology, Centre Hospitalier Jolimont, La Louvière, Belgium
Langenaeken, C.;  Department Medical Oncology, Iridium Cancer Network Antwerp, AZ Klina, Brasschaat, Belgium
Van Rijswijk, R.;  Department Medical Oncology, ZNA Stuivenberg, Antwerp, Belgium
Specenier, P.;  Department of Medical Oncology, University Hospital Antwerp, Antwerp, Belgium
JERUSALEM, Guy  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service d'oncologie médicale
Praet, J.-P.;  Department of Geriatric Medicine, CHU St-Pierre, Free Universities Brussels, Brussels, Belgium
Vandenborre, K.;  Department of Medical Oncology, AZ Vesalius, Tongeren, Belgium
Lobelle, J.-P.;  Consultant in Statistics, Beernem, Belgium
Lycke, M.;  Cancer Centre, General Hospital Groeninge, Kortrijk, Belgium & Positive Ageing Research Institute (PARI), Anglia Ruskin University, Chelmsford, United Kingdom
Milisen, K.;  Department of Geriatric Medicine, University Hospitals Leuven, Department of Public Health and Primary Care, Academic Centre for Nursing and Midwifery, KU Leuven, Leuven, Belgium
Wildiers, H.;  Department of General Medical Oncology, University Hospitals Leuven, Department of Oncology, KU Leuven, Leuven, Belgium
More authors (18 more) Less
Language :
English
Title :
Health related quality of life in older patients with solid tumors and prognostic factors for decline
Publication date :
2019
Journal title :
Journal of Geriatric Oncology
ISSN :
1879-4068
eISSN :
1879-4076
Publisher :
Elsevier Ltd
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 May 2019

Statistics


Number of views
97 (5 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
18
Scopus citations®
without self-citations
13
OpenCitations
 
19

Bibliography


Similar publications



Contact ORBi