[en] In most cases, Ewing sarcoma arises from a chromosomal translocation between the genes encoding a RNA-binding protein from the FET family (EWS) and a transcription factor from the ETS-superfamily (FLI1). Because the DNA-binding domain of FLI1 replaces the RNA-binding of EWS and is associated with a transactivation domain, the fusion protein EWS-FLI1 has early been viewed as an aberrant transcription factor. However, many evidences from litterature and our lab are challenging this view and led us to investigate a potential role in mRNA degradation for this oncoprotein.
Research Center/Unit :
GIGA‐R - Giga‐Research - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Galvan, Bartimée ; Université de Liège - ULiège > Molecular Biology of Diseases-Gene Expression & Cancer
Language :
English
Title :
The oncogenic transcription factor EWS-FLI1 drives mRNA instability in Ewing sarcoma
Alternative titles :
[fr] Le facteur de transcription oncogénique EWS-FLI1 conduit à l'instabilité de l'ARNm dans le sarcome d'Ewing
Publication date :
17 May 2019
Number of pages :
A0
Event name :
2nd Interdisciplinary PhD Student Day organized by the EDT BCMB
Event organizer :
Jason Perret, Catherine Sadzot
Event place :
Bruxelles, Belgium
Event date :
17 mai 2019
Name of the research project :
Contribution of mRNA decay to the oncogenic roles of FET-ETS fusion proteins
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
