Cardiovascular, respiratory, gastrointestinal and behavioral effects of intravenous lidocaine in healthy, conscious horses and evaluation of their relationship with lidocaine and monoethylglycinexylidide serum concentrations
[en] This study aimed to evaluate the relationship between the serum concentrations of lidocaine/
monoethylglycinexylidide (MEGX) and their effects on several systems in horses. Five healthy,
conscious horses received a two-hour placebo intravenous infusion followed by a two-hour lidocaine
infusion (bolus of 1.3 mg/kg over ten minutes followed by a continuous rate infusion of
0.05 mg/kg/min). Lidocaine and MEGX serum concentrations were sampled every ten to fifteen
minutes during the experiment, and the presence of muscle fasciculations and loss of balance as
well as the respiratory, digestive and cardiovascular systems of the five horses were evaluated by
means of different non-invasive methods. During the lidocaine infusion, the mean (± SD) lidocaine
and MEGX concentrations were respectively 768.88 ± 93.32ng/ml and 163.08 ± 108.98 ng/ml. The
infusion of lidocaine significantly influenced the presence of fasciculations, caused a statistically
but non-clinically significant decrease of systolic and diastolic blood pressures, which were both
correlated with lidocaine and MEGX serum concentrations, and it increased the duodenal contractions
frequency, which was correlated with the serum lidocaine concentration. In this study,
mild hypotensive and prokinetic effects of short-term lidocaine infusion were observed.
Busoni, Valeria ; Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Imagerie médicale
Detilleux, Johann ; Université de Liège - ULiège > Dpt. de gestion vétérinaire des Ressources Animales (DRA) > Génétique quantitative
Sandersen, Charlotte ; Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie et réanimation vétérinaires
Amory, Hélène ; Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des équidés
Language :
English
Title :
Cardiovascular, respiratory, gastrointestinal and behavioral effects of intravenous lidocaine in healthy, conscious horses and evaluation of their relationship with lidocaine and monoethylglycinexylidide serum concentrations
Alternative titles :
[nl] Cardiovasculaire, respiratoire, gastro-intestinale en gedragseffecten van intraveneuze lidocaïnetoediening bij gezonde paarden bij bewustzijn en evaluatie van de relatie met serumconcentraties van lidocaïne en mono-ethylglycinexylidide
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