Article (Scientific journals)
Blood pressure waveform contour analysis for assessing peripheral resistance changes in sepsis.
Davidson, Shaun; Pretty, Chris; Balmer, Joel et al.
2018In BioMedical Engineering OnLine, 17 (1), p. 171
Peer Reviewed verified by ORBi
 

Files


Full Text
PW contour analysis for assessing resistance changes in sepsis.pdf
Publisher postprint (2.25 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Arterial pressure waveform; Cardiovascular monitoring; Linear least-squares; Pressure catheter; Septic shock
Abstract :
[en] BACKGROUND: This paper proposes a methodology for helping bridge the gap between the complex waveform information frequently available in an intensive care unit and the simple, lumped values favoured for rapid clinical diagnosis and management. This methodology employs a simple waveform contour analysis approach to compare aortic, femoral and central venous pressure waveforms on a beat-by-beat basis and extract lumped metrics pertaining to the pressure drop and pressure-pulse amplitude attenuation as blood passes through the various sections of systemic circulation. RESULTS: Validation encompasses a comparison between novel metrics and well-known, analogous clinical metrics such as mean arterial and venous pressures, across an animal model of induced sepsis. The novel metric Ofe --> vc, the direct pressure offset between the femoral artery and vena cava, and the clinical metric, DeltaMP, the difference between mean arterial and venous pressure, performed well. However, Ofe --> vc reduced the optimal average time to sepsis detection after endotoxin infusion from 46.2 min for DeltaMP to 11.6 min, for a slight increase in false positive rate from 1.8 to 6.2%. Thus, the novel Ofe --> vc provided the best combination of specificity and sensitivity, assuming an equal weighting to both, of the metrics assessed. CONCLUSIONS: Overall, the potential of these novel metrics in the detection of diagnostic shifts in physiological behaviour, here driven by sepsis, is demonstrated.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Davidson, Shaun
Pretty, Chris
Balmer, Joel
Desaive, Thomas  ;  Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Chase, J. Geoffrey
Language :
English
Title :
Blood pressure waveform contour analysis for assessing peripheral resistance changes in sepsis.
Publication date :
2018
Journal title :
BioMedical Engineering OnLine
eISSN :
1475-925X
Publisher :
BioMed Central, United Kingdom
Volume :
17
Issue :
1
Pages :
171
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 May 2019

Statistics


Number of views
42 (1 by ULiège)
Number of downloads
40 (0 by ULiège)

Scopus citations®
 
3
Scopus citations®
without self-citations
3
OpenCitations
 
0

Bibliography


Similar publications



Contact ORBi