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Sarcopenic osteoarthritis: a new entity in geriatric medicine?

Veronese, N.; Punzi, L.; Sieber, C. et al.

2018 • In European Geriatric Medicine, 9 (2), p. 141-148

Peer reviewed

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https://hdl.handle.net/2268/235557

DOI
10.1007/s41999-018-0034-6

PubMed
34654260

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Keywords :

Osteoarthritis; Physical performance; Sarcopenia; Therapy; Review

Abstract :

[en] Purpose: Osteoarthritis, a disease characterized by cartilage degradation, abnormal subchondral bone remodeling and some grade of inflammation, and sarcopenia, a condition of low muscle mass associated with reduced strength and function, are prevalent disorders in older adults. In this review, we examine what is known about the relationship between osteoarthritis and sarcopenia, with particular focus on the older population. We also discuss how osteoarthritis and sarcopenia may interact and affect each other in clinical progression and the potential benefits from developing treatments that address such muscular-skeletal interaction. Methods: We searched in Pubmed and Scopus through a combination of search and MESH terms, for osteoarthritis and sarcopenia. Results: Even if more literature is needed, there is increasing evidence that decline in lower limb muscle strength is associated with knee or hip osteoarthritis in a pathological network of pain, altered joint stability, maladapted postures and defective neuromuscular communication. At the cellular levels, chondrocytes and myoblasts share common pathways, and the close anatomical location of both cell types also suggest the possibility of paracrine communication. Conclusions: Sarcopenia and osteoarthritis are significantly intercorrelated and in the near future should be considered as an only entity, as we have recently proposed for sarcopenia and osteoporosis. The treatment of both sarcopenia and osteoarthritis is based on physical exercise and nutritional interventions with the aim of improving cartilage, bone and muscle health. Future studies are needed, particularly to know the exact prevalence of sarcopenia in people with osteoarthritis, its peculiar consequences and the most appropriate treatments. © 2018, European Geriatric Medicine Society.

Disciplines :

General & internal medicine

Author, co-author :

Veronese, N.; National Research Council, Neuroscience Institute, Aging Branch, Via Giustiniani, 2, Padua, 35128, Italy

Punzi, L.; Rheumatology Unit, Department of Medicine (DIMED), University of Padova, Padua, Italy

Sieber, C.; Institute for Biomedicine of Aging, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nuremberg, Germany, Krankenhaus Barmherzige Brüder Regensburg, Regensburg, Germany

Bauer, J.; Center for Geriatric Medicine, Agaplesion Bethanien Krankenhaus Heidelberg, University of Heidelberg, Heidelberg, Germany

Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Maggi, S.; National Research Council, Neuroscience Institute, Aging Branch, Via Giustiniani, 2, Padua, 35128, Italy

On behalf of theTask Finish Group on Arthritis of the European Geriatric Medicine Society

Language :

English

Title :

Sarcopenic osteoarthritis: a new entity in geriatric medicine?

Publication date :

2018

Journal title :

European Geriatric Medicine

ISSN :

1878-7649

eISSN :

1878-7657

Publisher :

Springer International Publishing

Volume :

9

Issue :

2

Pages :

141-148

Peer reviewed :

Peer reviewed

Available on ORBi :

since 16 May 2019

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