Innocuité et efficacité d'un vaccin antirabique recombinant des virus de la vaccine et de la rage administré par voie orale au renard, au chien et au chat.
[en] One of the most promising ways to control rabies in wildlife seems to be the distribution of bait containing an anti-rabies vaccine. So far, the most widely used vaccines were modified live viruses (SAD strain or derivatives). Nevertheless, these strains retain some pathogenicity for non-target species. A novel vaccine was proposed consisting of genetically modified vaccinia virus (strain Copenhagen, thermosensitive ts 26) expressing the foreign glycoprotein G for the rabies virus (strain ERA). Different doses of this recombinant virus were administered orally to 59 foxes (Vulpes vulpes) and their antibodies were titrated before challenge. Foxes (8/8) resisted 1 month after vaccination with 10(7) plaque forming units (PFU), or 4/4 after 18 months. Seroconversion among dogs was 4/4 after vaccination with 10(9,6) PFU and 4/4 among cats after vaccination with 10(8) PFU. These dogs (4/4) and cats (3/4) resisted the challenge 2-3 months after vaccination. This vaccine thus appears to be potent and safe in these species. Its properties are discussed.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Blancou, J.; CNEVA, Laboratoire d'études sur la rage et la pathologie des animaux sauvages, Malzéville, France
Artois, M.; CNEVA, Laboratoire d'études sur la rage et la pathologie des animaux sauvages, Malzéville, France
Brochier, B.; Université de Liège, Faculté de médecine vétérinaire : Virologie, Immunologie et pathologie des maladies virales. Bruxelles
Thomas, I.; Université de Liège, Faculté de médecine vétérinaire : Virologie, Immunologie et pathologie des maladies virales. Bruxelles
Pastoret, Paul-Pierre ; Université de Liège, Faculté de médecine vétérinaire : Virologie, Immunologie et pathologie des maladies virales. Bruxelles
Desmettre, P.; Rhône Mérieux, Lyon, France
Languet, B.; Rhône Mérieux, Lyon, France
Kieny, M. P.; Transgène SA, Strasbourg, France
Language :
French
Title :
Innocuité et efficacité d'un vaccin antirabique recombinant des virus de la vaccine et de la rage administré par voie orale au renard, au chien et au chat.
Alternative titles :
[en] Safety and efficacy of an antirabies vaccine consisting of recombinant vaccinia-rabies virus administered orally to the fox, dog and cat
Publication date :
1989
Journal title :
Annales de Recherches Vétérinaires
ISSN :
0003-4193
Publisher :
Institut National de la Recherche Agronomique, France
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