The effect of Epigallocatechin-3-gallate on small intestinal morphology, antioxidant capacity and anti-inflammatory effect in heat-stressed broilers

Song, J.; Lei, X.; Luo, J.; Everaert, Nadia; Zhao, Guoying; Wen, J.; Yang, Y.

doi:10.1111/jpn.13062

Article (Scientific journals)

The effect of Epigallocatechin-3-gallate on small intestinal morphology, antioxidant capacity and anti-inflammatory effect in heat-stressed broilers

Song, J.; Lei, X.; Luo, J. et al.

2019 • In Journal of Animal Physiology and Animal Nutrition

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/235294

DOI
10.1111/jpn.13062

PubMed
30702179

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Keywords :

Epigallocatechin-3-gallate

Abstract :

[en] This study was to investigate the effects of Epigallocatechin-3-gallate (EGCG) on intestinal morphology, antioxidant capacity and anti-inflammatory response in heat-stressed broiler. A total of 192 2-week-old Arbour Acres broilers chickens were divided into four groups with six replicates per group and eight chickens per replicate: one thermoneutral control group (28°C, group TN), which was fed the basal diet; and three cyclic high-temperature groups (35°C from 7:00 to 19:00 hr; 28°C from 19:00 hr to 7:00 hr, heat stress group), which were fed the basal diet supplementation with EGCG 0 mg/kg (group HS0), 300 mg/kg (group HS300) and 600 mg/kg (group HS600). The gut morphology and intestinal mucosal oxidative stress indicators, as well as intestinal barrier-related gene expression, were analysed. The results showed that compared with group TN, heat stress reduced the villus height (VH), activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD)and catalase (CAT), increased the crypt depth (CD) and malondialdehyde (MDA)content at 21, 28 and 35 days (p < 0.05). After the heat-stressed broilers were supplemented with EGCG, VH, VH/CD (V/C), and the activities of GSH-Px, SOD and CAT were increased, and CD and MDA content were reduced compared with those in group HS0 without EGCG supplementation at 21, 28 and 35 days (p < 0.05). The EGCG supplementation promoted the gene expression of nuclear factor-erythroid 2-related factor 2 (Nrf2), Claudin-1, Mucin 2 (Muc2) and alleviated the nuclear factor-kappa B (NF-κB) and lipopolysaccharide-induced tumour necrosis factor (LITAF) gene expression compared with group HS0 (p < 0.05). Moreover, intestinal morphology was strongly correlated with antioxidant ability and inflammatory response. In conclusion, EGCG alleviated the gut oxidative injury of heat-stressed broilers by enhancing antioxidant capacity and inhibiting inflammatory response. © 2019 Blackwell Verlag GmbH

Disciplines :

Animal production & animal husbandry

Author, co-author :

Song, J.; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China

Lei, X.; College of Animal Science, Yangtze University, Jingzhou, China

Luo, J.; College of Animal Science, Yangtze University, Jingzhou, China

Everaert, Nadia ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Ingénierie des productions animales et nutrition

Zhao, Guoying

Wen, J.; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China

Yang, Y.; College of Animal Science, Yangtze University, Jingzhou, China

Language :

English

Title :

The effect of Epigallocatechin-3-gallate on small intestinal morphology, antioxidant capacity and anti-inflammatory effect in heat-stressed broilers

Publication date :

2019

Journal title :

Journal of Animal Physiology and Animal Nutrition

ISSN :

0931-2439

eISSN :

1439-0396

Publisher :

Blackwell Publishing Ltd

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 08 May 2019

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