Reference : Abaloparatide for risk reduction of nonvertebral and vertebral fractures in postmenop...
Scientific journals : Article
Human health sciences : General & internal medicine
http://hdl.handle.net/2268/235043
Abaloparatide for risk reduction of nonvertebral and vertebral fractures in postmenopausal women with osteoporosis: a network meta-analysis
English
Reginster, Jean-Yves mailto [Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Bianic, F. [Syneos Health, London, United Kingdom]
Campbell, R. [Syneos Health, London, United Kingdom]
Martin, M. [Syneos Health, London, United Kingdom]
Williams, S. A. [Radius Health, Inc., Waltham, MA, United States]
Fitzpatrick, L. A. [Radius Health, Inc., Waltham, MA, United States]
In press
Osteoporosis International
Springer London
Yes (verified by ORBi)
International
0937941X
14332965
[en] Abaloparatide ; ACTIVE ; Fracture prevention ; Network meta-analysis ; Postmenopausal osteoporosis ; Teriparatide
[en] Summary: This network meta-analysis assessed the efficacy of abaloparatide versus other treatment options to reduce the risk of fractures in women with postmenopausal osteoporosis. The analysis indicates that abaloparatide reduces the risk of fractures in women with postmenopausal osteoporosis versus placebo and compared with other treatment options. Introduction: This network meta-analysis (NMA) assessed the relative efficacy of abaloparatide versus other treatments to reduce the risk of fractures in women with postmenopausal osteoporosis (PMO). Methods: PubMed®, Embase®, and the Cochrane Central Register of Controlled Trials were searched for randomized controlled trials published before December 20, 2017, that included women with PMO who were eligible to receive interventions for primary or secondary fracture prevention. The NMA was conducted by fracture site (vertebral [VF], nonvertebral [NVF], and wrist), with the relative risk (RR) of fracture versus placebo the main clinical endpoint. The NMA used fixed-effects and random-effects approaches. Results: A total of 4978 articles were screened, of which 22 were included in the analysis. Compared with other treatments, abaloparatide demonstrated the greatest treatment effect relative to placebo in the VF network (RR = 0.13; 95% credible interval [CrI] 0.04–0.34), the NVF network (RR = 0.50; 95% CrI 0.28–0.85), and the wrist fracture network (RR = 0.39; CrI 0.15–0.90). Treatment ranking showed that abaloparatide had the highest estimated probability of preventing fractures in each of the networks (79% for VF, 70% for NVF, and 53% for wrist fracture) compared with other treatments. Individual networks demonstrated a good level of agreement with direct trial evidence and direct pair-wise comparisons. Conclusions: This NMA indicates that abaloparatide reduces the RR of VF, NVF, and wrist fracture in women with PMO with or without prior fracture versus placebo, compared with other treatment options. Limitations include that adverse events and drug costs were not considered, and that generalizability is limited to the trial populations and endpoints included in the NMA. © 2019, The Author(s).
http://hdl.handle.net/2268/235043
10.1007/s00198-019-04947-2

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Abaloparatide for risk reduction of nonvertebral and vertebral fractures in postmenopausal women with osteoporosis - a network meta-analysis..pdfPublisher postprint435.45 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.