Poster (Scientific congresses and symposiums)
Recent advance in the treatment of patients with disorders of consciousness: a review of transcranial direct current stimulation efficacy
Martens, Géraldine; Barra, Alice; Laureys, Steven et al.
20193rd International Brain Stimulation Conference
Editorial reviewed
 

Files


Full Text
tDCS_Review_Poster_final.pdf
Author postprint (354.17 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Severe brain injured patients with disorders of consciousness (DOC) represent a challenging population to treat. Non-invasive brain stimulation techniques, such as transcranial direct-current stimulation (tDCS) can transiently improve the level of consciousness of DOC patients, as measured with the Coma Recovery Scale-Revised (CRS-R). However, it is still unclear which proportion of patients can benefit from it, how long the effects can last and which brain region represent the best area to target. We here reviewed tDCS-based clinical trials on DOC to shed light on these issues. Eight articles met our criteria: three articles evaluated the effects of a single stimulation session and 5 articles assessed the effects of repeated stimulation sessions. The areas targeted by the stimulation in the articles included the following regions: the left dorsolateral prefrontal cortex (left DLPFC – F3, 5 studies), the posterior parietal cortex / precuneus (Pz, one study), the primary motor cortex (M1 - C3 or C4, one study) and the frontoparietal network bilaterally (F3, F4, CP5 and CP6, one study). Left DLPFC was the most used target, both for single and repeated session studies and has showed to effectively increase patient’s responsiveness in the CRS-R compared to other stimulated regions. Repeated session studies generally show larger effect size of tDCS treatment and higher number of responders as compared to single session. Furthermore, we found that the number of responders of repeated session studies (39 out of 110 in total) is significantly higher (p=0.0125) than the number of responders of single session studies (22 out of 111 in total). From this retrospective exploration of tDCS clinical trials, it emerged that the left DLPFC seems to be the most powerful and promising target to improve behavioural responsiveness of DOC patients whereas the strength and duration of tDCS aftereffects seems to increase with the number of sessions.
Disciplines :
Neurology
Author, co-author :
Martens, Géraldine  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Barra, Alice  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Laureys, Steven  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Thibaut, Aurore ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Language :
English
Title :
Recent advance in the treatment of patients with disorders of consciousness: a review of transcranial direct current stimulation efficacy
Publication date :
February 2019
Event name :
3rd International Brain Stimulation Conference
Event organizer :
Elsevier
Event place :
Vancouver, Canada
Event date :
from 24-02-2019 to 27-02-2019
Audience :
International
Peer reviewed :
Editorial reviewed
European Projects :
H2020 - 686764 - LUMINOUS - Studying, Measuring and Altering Consciousness through information theory in the electrical brain
Funders :
CE - Commission Européenne [BE]
Union Européenne [BE]
Available on ORBi :
since 21 April 2019

Statistics


Number of views
58 (7 by ULiège)
Number of downloads
120 (2 by ULiège)

Bibliography


Similar publications



Contact ORBi