[en] OBJECTIVE: Avoiding resection to treat posterior leaflet prolapse has become popular to repair degenerative mitral regurgitation. We never subscribed to such simplification but advocated an alternative approach based on the "respect when you can, resect when you should" concept. The present study reviewed posterior leaflet prolapse in degenerative disease with the aim to expose the 10-year experience with this surgical policy, in particular long-term outcomes such as survival, recurrent/severe mitral regurgitation, and reoperation. METHODS: From January 2005 to December 2015, 701 consecutive patients with severe mitral regurgitation underwent mitral valve repair in 2 distinct institutions. Mitral regurgitation was degenerative in 441 patients, of whom the 376 with posterior leaflet prolapse constituted the study population. Patients were followed up by echocardiograms until December 2017. Longitudinal data stratified by institution were analyzed by mixed-effects models. Outcome measures were analyzed by Kaplan-Meier test. RESULTS: Patients with posterior leaflet prolapse (24.7% isolated P2 and 75.3% P2 associated with other segments) were aged 65.8 +/- 13 years, and 70.5% were male. Median follow-up was 61.1 months. There were 3 hospital deaths (0.8%). Reoperation was necessary in 7 patients (1.9%). After 1, 5, and 10 years, overall survival was 97.8%, 93.6%, and 86.7%, respectively; the overall survival of the proportion of patients with recurrent/residual >2+ mitral regurgitation was estimated at 0.7%, 1.9%, and 5.9% and that of patients with New York Heart Association III/IV at 0.8%, 1.9%, and 5.3%. CONCLUSIONS: The "resect with respect" approach yields low operative mortality, no systolic anterior motion, good surface of coaptation, and low incidence of residual/recurrent mitral regurgitation and of reoperation, thus supporting resection when required concept.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Dreyfus, Gilles D.; Cardiothoracic Center of Monaco > Cardiac Surgery > Pr
Dulguerov, Filip; Cardiothoracic Center of Monaco > Cardiac Surgery > Dr
Marcacci, Cecilia; Cardiothoracic Center of Monaco > Cardiac Surgery
Gillinov, A.M., Blackstone, E.H., Nowicki, E.R., Slisatkorn, W., Al-Dossari, G., Johnston, D.R., et al. Valve repair versus valve replacement for degenerative mitral valve disease. J Thorac Cardiovasc Surg 135 (2008), 885–893.
Carpentier, A., Cardiac valve surgery: the “French correction”. J Thorac Cardiovasc Surg 86 (1983), 323–337.
Filsoufi, F., Carpentier, A., Principles of reconstructive surgery in degenerative mitral valve disease. Semin Thorac Cardiovasc Surg 19 (2007), 103–110.
Perier, P., Hohenberger, W., Lakew, F., Batz, G., Urbanski, P., Zacher, M., et al. Toward a new paradigm for the reconstruction of posterior leaflet prolapse: midterm results of the “respect rather than resect” approach. Ann Thorac Surg 86 (2008), 718–725.
Dreyfus, G.D., Corbi, P., Rubin, S., Aubert, S., Posterior leaflet preservation in mitral valve prolapse: a new approach to mitral repair. J Heart Valve Dis 15 (2006), 528–530.
Suri, R.M., Burkhart, H.M., Schaff, H.V., A novel method of leaflet reconstruction after triangular resection for posterior mitral valve prolapse. Ann Thorac Surg 89 (2010), 53–56.
Carpentier, A., The sliding leaflet technique. Le Club Mitrale Newsletter 1 (1988), 2–3.
Mazine, A., Friedrich, J.O., Nedadur, R., Verma, S., Ouzounian, M., Juni, P., et al. Systematic review and meta-analysis of chordal replacement versus leaflet resection for posterior mitral leaflet prolapse. J Thorac Cardiovasc Surg 155 (2018), 120–128.e10.
Tomsic, A., Klautz, R.J., Palmen, M., Respect versus resect: two different repair techniques or two different tools in the box?. J Thorac Cardiovasc Surg 155 (2018), 600–601.
Antunes, M.J., Isolated posterior mitral leaflet prolapse: resect, respect, or resect with respect?. J Thorac Cardiovasc Surg 155 (2018), 129–130.
Padala, M., Cardinau, B., Gyoneva, L.I., Thourani, V.H., Yoganathan, A.P., Comparison of artificial neochordae and native chordal transfer in the repair of a flail posterior mitral leaflet: an experimental study. Ann Thorac Surg 95 (2013), 629–633.
Nardi, P., Pellegrino, A., Olevano, C., Scafuri, A., Lio, A., Polisca, P., et al. Mitral valve repair for the treatment of degenerative mitral valve disease with or without prosthetic ring annuloplasty: long-term outcomes. J Cardiovasc Surg 54 (2013), 305–312.
Braunberger, E., Deloche, A., Berrebi, A., Abdallah, F., Celestin, J.A., Meimoun, P., et al. Very long term results (more than 20 years) of valve repair with Carpentier's techniques in non rheumatic mitral valve insufficiency. Circulation 104:12 Suppl 1 (2001), I8–I11.
Jebara, V.A., Mihaileanu, S., Acar, C., Brizard, C., Grare, P., Latremouille, C., et al. Left ventricular outflow tract obstruction after mitral valve repair. Result of the sliding leaflet technique. Circulation 88:5 Pt 2 (1993), II30–II34.
Carpentier, A., The SAM issue. Le Club MitraleNewsletter 1 (1989), 72–75.