Post-remission strategies for the prevention of relapse following allogeneic hematopoietic cell transplantation for high-risk acute myeloid leukemia: expert review from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Lee, C. J.; Savani, B. N.; Mohty, M.; Gorin, N. C.; Labopin, M.; Ruggeri, A.; Schmid, C.; Baron, Frédéric; Esteve, J.; Giebel, S.; Ciceri, F.; Nagler, A.

doi:10.1038/s41409-018-0286-2

Article (Scientific journals)

Post-remission strategies for the prevention of relapse following allogeneic hematopoietic cell transplantation for high-risk acute myeloid leukemia: expert review from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Lee, C. J.; Savani, B. N.; Mohty, M. et al.

2019 • In Bone Marrow Transplantation, 54, p. 519-530

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https://hdl.handle.net/2268/234315

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10.1038/s41409-018-0286-2

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30104717

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Abstract :

[en] Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy generally associated with poor prognosis. Allogeneic hematopoietic cell transplantation (alloHCT) continues to be the most potent anti-leukemia treatment for adult patients with intermediate and high-risk AML. However, disease relapse after alloHCT remains unacceptably high and is the primary cause of treatment failure and mortality following alloHCT. It is therefore that post-transplant early cellular or pharmacologic maintenance or preemptive strategies to enhance the graft-versus-leukemia effect or to eradicate persistent minimal residual disease have been of renewed interest, particularly with the availability of more sensitive technologies to measure residual AML. Although preliminary studies have demonstrated improved outcomes with the use of post-alloHCT remission therapies, prospective randomized trials are required to determine their clinical efficacy and role in the treatment of AML. On behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we summarize the available evidence on the use and efficacy of available pharmacologic post-remission therapies, including hypomethylating agents, deacetylase inhibitors, and tyrosine kinase inhibitors, as well as cellular therapies, including preemptive and prophylactic donor lymphocyte infusions for the prevention of relapse of AML. © 2018, Springer Nature Limited.

Disciplines :

Hematology

Author, co-author :

Lee, C. J.; Utah Blood and Marrow Transplant Program, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States

Savani, B. N.; Vanderbilt University Medical Center, Nashville, TN, United States

Mohty, M.; Department of Hematology, Hopital Saint-Antoine, APHP and University UPMC, Paris, France

Gorin, N. C.; Department of Hematology, Hopital Saint-Antoine, APHP and University UPMC, Paris, France

Labopin, M.; Department of Haematology, Hopital Saint-Antoine, INSERM, Paris, France

Ruggeri, A.; Department of Haematology, Hopital Saint-Antoine, INSERM, Paris, France

Schmid, C.; Klinikum Augsburg, Dept. of Hematology and Oncology, University of Munich, Augsburg, Germany

Baron, Frédéric ; Université de Liège - ULiège > GIGA-R : Hématologie

Esteve, J.; Department of Hematology, Hospital Clinic, IDIBAPS, Barcelona, Spain

Giebel, S.; Maria Sklodowska-Curie Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Ciceri, F.; Department of Hematology, IRCCS San Raffaele Scientific Institute, Milano, Italy

Nagler, A.; Hematology Division, Chaim Sheba Medical Center, Tel Hashomer, Israel, Acute Leukemia Working Party – EBMT Paris office, Hȏpital Saint-Antoine, Paris, France

Language :

English

Title :

Publication date :

2019

Journal title :

Bone Marrow Transplantation

ISSN :

0268-3369

eISSN :

1476-5365

Publisher :

Nature Publishing Group

Volume :

Pages :

519-530

Peer reviewed :

Peer Reviewed verified by ORBi

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