Reference : Fundamental Studies on Poly(2-oxazoline) Side Chain Isomers Using Tandem Mass Spectro...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/234258
Fundamental Studies on Poly(2-oxazoline) Side Chain Isomers Using Tandem Mass Spectrometry and Ion Mobility-Mass Spectrometry
English
Haler, Jean mailto [Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique >]
de la Rosa, Victor R. mailto [Ghent University > > Supramolecular Chemistry Group > >]
Massonnet, Philippe mailto [Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique >]
Far, Johann mailto [Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique >]
Hoogenboom, Richard mailto [Ghent University > > Supramolecular Chemistry Group > >]
De Pauw, Edwin mailto [Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique >]
In press
Journal of the American Society for Mass Spectrometry
Springer
Yes (verified by ORBi)
International
1044-0305
1879-1123
New-York
NY
[en] Poly(2-oxazoline)s ; Synthetic polymer isomers ; Tandem mass spectrometry MS/MS ; Collision-induced dissociation ; Ion mobility-mass spectrometry
[en] When polymer mixtures become increasingly complex, the conventional analysis techniques become insufficient for complete characterization. Mass spectrometric techniques can satisfy this increasing demand for detailed sample characterization. Even though isobaric polymers are indistinguishable using simple mass spectrometry (MS) analyses, more advanced techniques such as tandem MS (MS/MS) or ion mobility (IM) can be used. Here, we report proof of concept for characterizing isomeric polymers, namely poly(2-n-propyl-2-oxazoline) (Pn-PrOx) and poly(2-isopropyl-2-oxazoline) (Pi-PrOx), using MS/MS and IM-MS. Pi-PrOx ions lose in intensity at higher accelerating voltages than Pn-PrOx ions during collision-induced dissociation (CID) MS/MS experiments. A Pn/i-PrOx mixture could also be titrated using survival yield calculations of either precursor ions or cation ejection species. IM-MS yielded shape differences in the degree of polymerization (DP) regions showing the structural rearrangements. Combined MS techniques are thus able to identify and deconvolute the molar mass distributions of the two isomers in a mixture. Finally, the MS/MS and IM-MS behaviors are compared for interpretation.
Molecular Systems - MolSys
Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; Fonds Wetenschappelijk Onderzoek - Vlaanderen - FWO ; Ghent University
http://hdl.handle.net/2268/234258
10.1007/s13361-019-02173-y
https://link.springer.com/article/10.1007/s13361-019-02173-y

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