Fundamental Studies on Poly(2-oxazoline) Side Chain Isomers Using Tandem Mass Spectrometry and Ion Mobility-Mass Spectrometry

Haler, Jean; de la Rosa, Victor R.; Massonnet, Philippe; Far, Johann; Hoogenboom, Richard; De Pauw, Edwin

doi:10.1007/s13361-019-02173-y

Article (Scientific journals)

Fundamental Studies on Poly(2-oxazoline) Side Chain Isomers Using Tandem Mass Spectrometry and Ion Mobility-Mass Spectrometry

Haler, Jean; de la Rosa, Victor R.; Massonnet, Philippe et al.

2019 • In Journal of the American Society for Mass Spectrometry

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/234258

DOI
10.1007/s13361-019-02173-y

PubMed
30949970

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Keywords :

Poly(2-oxazoline)s; Synthetic polymer isomers; Tandem mass spectrometry MS/MS; Collision-induced dissociation; Ion mobility-mass spectrometry

Abstract :

[en] When polymer mixtures become increasingly complex, the conventional analysis techniques become insufficient for complete characterization. Mass spectrometric techniques can satisfy this increasing demand for detailed sample characterization. Even though isobaric polymers are indistinguishable using simple mass spectrometry (MS) analyses, more advanced techniques such as tandem MS (MS/MS) or ion mobility (IM) can be used. Here, we report proof of concept for characterizing isomeric polymers, namely poly(2-n-propyl-2-oxazoline) (Pn-PrOx) and poly(2-isopropyl-2-oxazoline) (Pi-PrOx), using MS/MS and IM-MS. Pi-PrOx ions lose in intensity at higher accelerating voltages than Pn-PrOx ions during collision-induced dissociation (CID) MS/MS experiments. A Pn/i-PrOx mixture could also be titrated using survival yield calculations of either precursor ions or cation ejection species. IM-MS yielded shape differences in the degree of polymerization (DP) regions showing the structural rearrangements. Combined MS techniques are thus able to identify and deconvolute the molar mass distributions of the two isomers in a mixture. Finally, the MS/MS and IM-MS behaviors are compared for interpretation.

Research center :

MolSys - Molecular Systems - ULiège

Disciplines :

Chemistry

Author, co-author :

Haler, Jean ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique

de la Rosa, Victor R.; Ghent University > Supramolecular Chemistry Group

Massonnet, Philippe ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique

Far, Johann ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique

Hoogenboom, Richard; Ghent University > Supramolecular Chemistry Group

De Pauw, Edwin ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique

Language :

English

Title :

Fundamental Studies on Poly(2-oxazoline) Side Chain Isomers Using Tandem Mass Spectrometry and Ion Mobility-Mass Spectrometry

Publication date :

2019

Journal title :

Journal of the American Society for Mass Spectrometry

ISSN :

1044-0305

eISSN :

1879-1123

Publisher :

Springer, New-York, United States - New York

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://link.springer.com/article/10.1007/s13361-019-02173-y

Funders :

FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
FWO - Fonds Wetenschappelijk Onderzoek Vlaanderen [BE]
UGent - Universiteit Gent [BE]

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