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Abstract :
[en] We recently described the presence of a TSH receptor variant in orbital tissues. The presence of this TSH receptor variant in the thymus suggests that induction of immune tolerance to this TSH receptor-transcript is possible. A lack of tolerance induction for this TSH receptor variant could provide an explanation for a possible antigenic link between Graves' disease and thyroid-associated orbitopathy.
Disciplines :
Endocrinology, metabolism & nutrition
Immunology & infectious disease
Biochemistry, biophysics & molecular biology
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