Eph/ephrin signalling in the development and function of the mammalian cochlea.

[en] In mammals, the functional development of the cochlea requires the tight regulation of multiple molecules and signalling pathways including fibroblast growth factors, bone morphogenetic proteins, Wnt and Notch signalling pathways. Over the last decade, the Eph/ephrin system also emerged as a key player of the development and function of the mammalian cochlea. In this review, we discuss the recent advances on the role of Eph/ephrin signalling in patterning the cochlear sensory epithelium and the complex innervation of mechanosensory hair cells by spiral ganglion neurons. Finally, we address the issue of a syndromic form of hearing loss caused by a deficient member of the Eph/ephrin family.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Defourny, Jean ; Université de Liège - ULiège > Neurosciences-Cellular and tissular biology

Language :

English

Title :

Eph/ephrin signalling in the development and function of the mammalian cochlea.

Publication date :

2019

Journal title :

Developmental Biology

ISSN :

0012-1606

eISSN :

1095-564X

Publisher :

Elsevier, Atlanta, United States - Florida

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 26 February 2019

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