[en] The secreted phosphatidylserine-binding protein milk fat globule epidermal growth factor 8 (Mfge8) mediates engulfment of apoptotic germinal center B cells by tingible-body macrophages (TBMphis). Impairment of this process can contribute to autoimmunity. We show that Mfge8 is identical to the mouse follicular dendritic cell (FDC) marker FDC-M1. In bone-marrow chimeras between wild-type and Mfge8(-/-) mice, all splenic Mfge8 was derived from FDCs rather than TBMphis. However, Mfge8(-/-) TBMphis acquired and displayed Mfge8 only when embedded in Mfge8(+/+) stroma, or when situated in lymph nodes draining exogenous recombinant Mfge8. These findings indicate a licensing role for FDCs in TBMphi-mediated removal of excess B cells. Lymphotoxin-deficient mice lacked FDCs and splenic Mfge8, and suffer from autoimmunity similar to Mfge8(-/-) mice. Hence, FDCs facilitate TBMphi-mediated corpse removal, and their malfunction may be involved in autoimmunity.
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Chen, L.L., J.C. Adams, and R.M. Steinman. 1978. Anatomy of germinal centers in mouse spleen, with special reference to "follicular dendritic cells". J. Cell Biol. 77:148-164.
Tew, J.G., G.J. Thorbecke, and R.M. Steinman. 1982. Dendritic cells in the immune response: characteristics and recommended nomenclature (A report from the Reticuloendothelial Society Committee on Nomenclature). J. Reticuloendothel. Soc. 31:371-380.
Tew, J.G., J. Wu, M. Fakher, A.K. Szakal, and D. Qin. 2001. Follicular dendritic cells: beyond the necessity of T-cell help. Trends Immunol. 22:361-367.
Klaus, G.G., J.H. Humphrey, A. Kunkl, and D.W. Dongworth. 1980. The follicular dendritic cell: its role in antigen presentation in the generation of immunological memory. Immunol. Rev. 53:3-28.
Kosco-Vilbois, M.H. 2003. Are follicular dendritic cells really good for nothing? Nat. Rev. Immunol. 3:764-769.
Hannum, L.G., A.M. Haberman, S.M. Anderson, and M.J. Shlomchik. 2000. Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells. J. Exp. Med. 192:931-942.
Matsumoto, M., S.F. Lo, C.J. Carruthers, J. Min, S. Mariathasan, G. Huang, D.R. Plas, S.M. Martin, R.S. Geha, M.H. Nahm, and D.D. Chaplin. 1996. Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice. Nature. 382:462-466.
Taylor, P.R., M.C. Pickering, M.H. Kosco-Vilbois, M.J. Walport, M. Botto, S. Gordon, and L. Martinez-Pomares. 2002. The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues. Eur. J. Immunol. 32:1888-1896.
Kosco, M.H., E. Pflugfelder, and D. Gray. 1992. Follicular dendritic cell-dependent adhesion and proliferation of B cells in vitro. J. Immunol. 148:2331-2339.
Hanayama, R., M. Tanaka, K. Miyasaka, K. Aozasa, M. Koike, Y. Uchiyama, and S. Nagata. 2004. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science. 304:1147-1150.
Hanayama, R., M. Tanaka, K. Miwa, A. Shinohara, A. Iwamatsu, and S. Nagata. 2002. Identification of a factor that links apoptotic cells to phagocytes. Nature. 417:182-187.
Stubbs, J.D., C. Lekutis, K.L. Singer, A. Bui, D. Yuzuki, U. Srinivasan, and G. Parry. 1990. cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences. Proc. Natl. Acad. Sci. USA. 87:8417-8421.
Thielen, C., N. Antoine, F. Melot, J.Y. Cesbron, E. Heinen, and R. Tsunoda. 2001. Human FDC express PrPc in vivo and in vitro. Dev. Immunol. 8:259-266.
Humphrey, J.H., D. Grennan, and V. Sundaram. 1984. The origin of follicular dendritic cells in the mouse and the mechanism of trapping of immune complexes on them. Eur. J. Immunol. 14:859-864.
Kapasi, Z.F., D. Qin, W.G. Kerr, M.H. Kosco-Vilbois, L.D. Shultz, J.G. Tew, and A.K. Szakal. 1998. Follicular dendritic cell (FDC) precursors in primary lymphoid tissues. J. Immunol. 160:1078-1084.
Yoshida, K., M. Kaji, T. Takahashi, T.K. van den Berg, and C.D. Dijkstra. 1995. Host origin of follicular dendritic cells induced in the spleen of SCID mice after transfer of allogeneic lymphocytes. Immunology. 84:117-126.
Sukumar, S., A.K. Szakal, and J.G. Tew. 2006. Isolation of functionally active murine follicular dendritic cells. J. Immunol. Methods. 313:81-95.
Shi, K., K. Hayashida, M. Kaneko, J. Hashimoto, T. Tomita, P.E. Lipsky, H. Yoshikawa, and T. Ochi. 2001. Lymphoid chemokine B cell-attracting chemokine-1 (CXCL13) is expressed in germinal center of ectopic lymphoid follicles within the synovium of chronic arthritis patients. J. Immunol. 166:650-655.
Pasparakis, M., S. Kousteni, J. Peschon, and G. Kollias. 2000. Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles. Cell. Immunol. 201:33-41.
Schwaeble, W., M.K. Schafer, F. Petry, T. Fink, D. Knebel, E. Weihe, and M. Loos. 1995. Follicular dendritic cells, interdigitating cells, and cells of the monocyte-macrophage lineage are the C1q-producing sources in the spleen. Identification of specific cell types by in situ hybridization and immunohistochemical analysis. J. Immunol. 155:4971-4978.
Walport, M.J., K.A. Davies, and M. Botto. 1998. C1q and systemic lupus erythematosus. Immunobiology. 199:265-285.
Futterer, A., K. Mink, A. Luz, M.H. Kosco-Vilbois, and K. Pfeffer. 1998. The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity. 9:59-70.
Fu, Y.X., and D.D. Chaplin. 1999. Development and maturation of secondary lymphoid tissues. Annu. Rev. Immunol. 17:399-433.
Chin, R.K., J.C. Lo, O. Kim, S.E. Blink, P.A. Christiansen, P. Peterson, Y. Wang, C. Ware, and Y.X. Fu. 2003. Lymphotoxin pathway directs thymic Aire expression. Nat. Immunol. 4:1121-1127.
Rossi, S.W., M.Y. Kim, A. Leibbrandt, S.M. Parnell, W.E. Jenkinson, S.H. Glanville, F.M. McConnell, H.S. Scott, J.M. Penninger, E.J. Jenkinson, et al. 2007. RANK signals from CD4+3- inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J. Exp. Med. 204:1267-1272.
Boehm, T., S. Scheu, K. Pfeffer, and C.C. Bleul. 2003. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTβR. J. Exp. Med. 198:757-769.
Venanzi, E.S., D.H. Gray, C. Benoist, and D. Mathis. 2007. Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected. J. Immunol. 179:5693-5700.
Bueler, H., M. Fischer, Y. Lang, H. Bluethmann, H.P. Lipp, S.J. DeArmond, S.B. Prusiner, M. Aguet, and C. Weissmann. 1992. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature. 356:577-582.
Koni, P.A., R. Sacca, P. Lawton, J.L. Browning, N.H. Ruddle, and R.A. Flavell. 1997. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity. 6:491-500.
Zullig, S., and M.O. Hengartner. 2004. Cell biology. Tickling macrophages, a serious business. Science. 304:1123-1124
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.
