Article (Scientific journals)
Downregulation of miRNA-29, -23 and -21 in urine of Duchenne muscular dystrophy patients.
Catapano, Francesco; Domingos, Joana; Perry, Mark et al.
2018In Epigenomics, 10 (7), p. 875-889
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Keywords :
Duchenne muscular dystrophy; biomarker; deflazacort; exosome; miRNA; prednisolone
Abstract :
[en] AIM: To study the signature of 87 urinary miRNAs in Duchenne muscular dystrophy (DMD) patients, select the most dysregulated and determine statistically significant differences in their expression between controls, ambulant (A) and nonambulant (NA) DMD patients, and patients on different corticosteroid regimens. Patients/materials & methods: Urine was collected from control (n = 20), A (n = 31) and NA (n = 23) DMD patients. miRNA expression was measured by reverse transcription-quantitative PCR. RESULTS: miR-29c-3p was significantly downregulated in A DMD patients while miR-23b-3p and miR-21-5p were significantly downregulated in NA DMD patients compared with age-matched controls. CONCLUSION: miR-29c-3p, miR-23b-3p and miR-21-5p are promising novel noninvasive biomarkers for DMD, and miR-29c-3p levels are differentially affected by different steroid regimens, supporting the antifibrotic effect of steroid therapy.
Disciplines :
Neurology
Pediatrics
Author, co-author :
Catapano, Francesco
Domingos, Joana
Perry, Mark
Ricotti, Valeria
Phillips, Lauren
Servais, Laurent ;  Université de Liège - ULiège > Département des sciences cliniques > Neuropédiatrie
Seferian, Andreea
Groot, Imelda De
Krom, Yvonne D.
Niks, Erik H.
Verschuuren, Jan Jgm
Straub, Volker
Voit, Thomas
Morgan, Jennifer
Muntoni, Francesco
More authors (5 more) Less
Language :
English
Title :
Downregulation of miRNA-29, -23 and -21 in urine of Duchenne muscular dystrophy patients.
Publication date :
2018
Journal title :
Epigenomics
ISSN :
1750-1911
eISSN :
1750-192X
Publisher :
Future Medicine, London, United Kingdom
Volume :
10
Issue :
7
Pages :
875-889
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 14 February 2019

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