Sulindac encapsulation and release from functional poly(HEMA) microparticles prepared in supercritical carbon dioxide

[en] Sulindac loaded poly(HEMA) cross-linked microparticles were synthesized via one-pot free-radical dispersion polymerisation in supercritical carbon dioxide (scCO2) in presence of photocleavable diblock stabilisers based on polyethylene oxide (PEO) and poly(heptadecafluorodecyl acrylate) (PFDA) bearing a o-nitrobenzyl photosensitive junction (hv) (PEO-hv-PFDA), and ethylene glycol dimethacrylate (EGDMA) as cross-linker. Poly(HEMA) cross-linked microparticles either empty or sulindac loaded were obtained with well-defined spherical morphology with the sizes between 250 and 350 nm. Additionally, upon UV-photolysis the stabiliser on the surface was cleaved which permits to microparticles to be redispersed in water leading to water swollen microgels about 2.1–3.6 µm. Moreover, the release behaviour from obtained microgels indicated the sustained release of sulindac over 10 days. Besides, the surface modification after UV-photolysis was studied and proved that the particles can be functionalised with further chemistries. © 2018 Elsevier B.V.

Research center :

CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège
Center for Education and Research on Macromolecules (CERM)

Disciplines :

Materials science & engineering
Chemistry

Author, co-author :

Parilti, Rahmet; University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)

Riva, Raphaël ; University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)

Howdle, Steven M.; University of Nottingham, School of Chemistry, UK

Dupont-Gillain, Christine; Université catholique de Louvain (UCL), Institute of Condensed Matter and Nanosciences (IMCN), Bio and Soft Matter Division (BSMA)

Jérôme, Christine ; University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)

Language :

English

Title :

Sulindac encapsulation and release from functional poly(HEMA) microparticles prepared in supercritical carbon dioxide

Publication date :

05 October 2018

Journal title :

International Journal of Pharmaceutics

ISSN :

0378-5173

eISSN :

1873-3476

Publisher :

Elsevier B.V.

Volume :

549

Issue :

1-2

Pages :

161-168

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

The Erasmus Mundus Joint Doctorate programe in the frame of "Nanofar"
The Walloon Region in the frame of the "Smartdif" project
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique

Available on ORBi :

since 13 February 2019

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