Localization of interleukin 6 mRNA in human tonsils by in situ hybridization.

Bosseloir, A.; Hooghe-Peters, E. L.; Heinen, Ernst; Cormann, N.; Kinet-Denoel, C.; Vanhaelst, L.; Simar, L.

doi:10.1002/eji.1830191230

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Article (Scientific journals)

Localization of interleukin 6 mRNA in human tonsils by in situ hybridization.

Bosseloir, A.; Hooghe-Peters, E. L.; Heinen, Ernst et al.

1989 • In European Journal of Immunology, 19 (12), p. 2379-81

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https://hdl.handle.net/2268/23268

DOI
10.1002/eji.1830191230

PubMed
2606144

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Keywords :

B-Lymphocytes/physiology; DNA Probes; Humans; Interleukin-6/genetics; Nucleic Acid Hybridization; Palatine Tonsil/cytology/physiology; RNA, Messenger/genetics

Abstract :

[en] We have investigated which areas produce interleukin 6 (IL 6) in human tonsils. This growth factor is required for the terminal differentiation of B lymphocytes into plasmocytes. Using 35S-labeled IL 6 cDNA we demonstrated IL 6 gene expression over various areas of the tonsils, with consistent exception of the follicles, by in situ hybridization. It is, therefore, proposed that B cells are stimulated during their migration out of the follicles.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Bosseloir, A.

Hooghe-Peters, E. L.

Heinen, Ernst ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine

Cormann, N.

Kinet-Denoel, C.

Vanhaelst, L.

Simar, L.

Language :

English

Title :

Localization of interleukin 6 mRNA in human tonsils by in situ hybridization.

Publication date :

1989

Journal title :

European Journal of Immunology

ISSN :

0014-2980

eISSN :

1521-4141

Publisher :

VCH Verlagsgesellschaft, Weinheim, Germany

Volume :

Issue :

Pages :

2379-81

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 30 June 2011

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