Integration of Low-Power ASIC and MEMS Sensors for Monitoring Gastrointestinal Tract Using a Wireless Capsule System

Application specific integrated circuit (ASIC); Antennas; Application specific integrated circuits; Capacitive sensors; Frequency modulation; Microsystems; Modulation; Printed circuit boards; Pulse width modulation; Voltage control; Conformal antennas; Gastrointestinal tract; Interface circuits; Lower-power consumption; Real time measurements; System miniaturization; Wireless capsule; Wireless capsule application; Radio transceivers

Abstract :

[en] This paper presents a wireless capsule microsystem to detect and monitor the pH, pressure, and temperature of the gastrointestinal tract in real time. This research contributes to the integration of sensors (microfabricated capacitive pH, capacitive pressure, and resistive temperature sensors), frequency modulation and pulse width modulation based interface IC circuits, microcontroller, and transceiver with meandered conformal antenna for the development of a capsule system. The challenges associated with the system miniaturization, higher sensitivity and resolution of sensors, and lower power consumption of interface circuits are addressed. The layout, PCB design, and packaging of a miniaturized wireless capsule, having diameter of 13 mm and length of 28 mm, have successfully been implemented. A data receiver and recorder system is also designed to receive physiological data from the wireless capsule and to send it to a computer for real-time display and recording. Experiments are performed in vitro using a stomach model and minced pork as tissue simulating material. The real-time measurements also validate the suitability of sensors, interface circuits, and meandered antenna for wireless capsule applications. © 2013 IEEE.

Disciplines :

Electrical & electronics engineering

Author, co-author :

Arefin, M. S.; Department of Electrical and Computer Systems Engineering, Monash University, Melbourne, VIC 3800, Australia

Redouté, Jean-Michel ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes microélectroniques intégrés

Yuce, M. R.; Department of Electrical and Computer Systems Engineering, Monash University, Melbourne, VIC 3800, Australia

Language :

English

Title :

Integration of Low-Power ASIC and MEMS Sensors for Monitoring Gastrointestinal Tract Using a Wireless Capsule System

Publication date :

2018

Journal title :

IEEE Journal of Biomedical and Health Informatics

ISSN :

2168-2194

eISSN :

2168-2208

Publisher :

Institute of Electrical and Electronics Engineers Inc.

Volume :

Issue :

Pages :

87-97

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

Monash University

Available on ORBi :

since 04 February 2019

Statistics

Number of views

62 (11 by ULiège)

Number of downloads

0 (0 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

T. B. Tang et al., "Toward a miniature wireless integrated multisensor microsystem for industrial and biomedical applications, " IEEE Sensors J., vol. 2, no. 6, pp. 628-635, Dec. 2002.
T. B. Tang et al., "IDEAS: Aminiature lab-in-a-pill multisensormicrosystem, " in Proc. IEEE NORCHIP Conf., Copenhagen, Denmark, 2002, pp. 329-334.
K. Morimoto and H. Suzuki, "Micro analysis system for pH and protease activities with an integrated sample injection mechanism, " Biosensors Bioelectron., vol. 22, no. 1, pp. 86-93, Jul. 2006.
K. Kalantar-zadeh et al., "Intestinal gas capsules: A proof-of-concept demonstration, " Gastroenterology, vol. 150, no. 1 pp. 37-39, Jan. 2016.
C. Mc Caffrey, O. Chevalerias, C. O'Mathuna, and K. Twomey, "Swallowable-capsule technology, " IEEE Pervasive Comput., vol. 7, no. 1, pp. 23-29, Jan.-Mar. 2008.
M. R. Yuce and T. Dissanayake, "Easy-to-swallow wireless telemetry, " IEEE Microw. Mag., vol. 13, no. 6, pp. 90-101, Sep./Oct. 2012.
H. Cao et al., "An implantable, batteryless, and wireless capsule with integrated impedance and pH sensors for gastroesophageal refluxmonitoring, " IEEE Trans. Biomed. Eng., vol. 59, no. 11, pp. 3131-3139, Nov. 2012.
SmartPill motility testing system fromGiven Imaging Ltd., 2006. [Online] Available: http://www. givenimaging. com/en-int/Innovative-Solutions/Motility/SmartPill/Pages/default. aspx, Accessed on: Mar. 30, 2017.
E. A. Johannessen, L. Wang, C. Wyse, D. R. S. Cumming, and J. M. Cooper, "Biocompatibility of a lab-on-a-pill sensor in artificial gastrointestinal environments, " IEEE Trans. Biomed. Eng., vol. 53, no. 11, pp. 2333-2340, Nov. 2006.
F. Xu, G. Yan, K. Zhao, L. Lu, J. Gao, and G. Liu, "A wireless capsule system with ASIC for monitoring the physiological signals of the human gastrointestinal tract, " IEEE Trans. Biomed. Circuits Syst., vol. 8, no. 6, pp. 871-880, Dec. 2014.
P. A. Hammond, D. Ali, and D. R. S. Cumming, "A system-on-chip digital pH meter for use in a wireless diagnostic capsule, " IEEE Trans. Biomed. Eng., vol. 52, no. 4, pp. 687-694, Apr. 2005.
K. Zhao, G. Yan, L. Lu, and F. Xu, "Low-power wireless electronic capsule for long-term gastrointestinal monitoring, " J. Med. Syst., vol. 39, no. 2, p. 9, Feb. 2015.
G. Pan and L. Wang, "Swallowable wireless capsule endoscopy: progress and technical challenges, " Gastroenterol. Res. Pract., vol. 2012, Oct. 2012, Art. no. 841691.
A. Arshak et al., "Review of the potential of a wireless MEMS and TFT microsystems for the measurement of pressure in the GI tract, " Med. Eng. Phys., vol. 27, no. 5, pp. 347-358, Jun. 2005.
S. Schostek et al., "Telemetric real-time sensor for the detection of acute upper gastrointestinal bleeding, " Biosensors Bioelectron., vol. 78, pp. 524-529, Apr. 2016.
P. Valdastri, A. Menciassi, A. Arena, C. Caccamo, and P. Dario, "An implantable telemetry platform system for in vivo monitoring of physiological parameters, " IEEE Trans. Inf. Technol. Biomed., vol. 8, no. 3, pp. 271-278, Sep. 2004.
E. A. Johannessen et al., "An ingestible electronic pill for real time analytical measurement of the gastro-intestinal tract, " in Micro Total Analysis Systems. Dordrecht, The Netherlands: Springer-Verlag, 2002, pp. 181-183.
R. S. Mackay and B. Jacobson, "Endoradiosonde, " Nature, vol. 179, no. 4572, pp. 1239-1240, May 1957.
V. K. Zworykin, "A radio pill, " Nature, vol. 179, no. 4566, p. 898, Jun. 1957.
S. Kumar, "The effect of sustained spinal load on intra-abdominal pressure and EMG characteristics of trunk muscles, " Ergonomics, vol. 40, no. 12, pp. 1312-1334, Dec. 1997.
P. N. Cutchis, A. F. Hogrefe, and J. C. Lesho, "The ingestible thermal monitoring system, " Johns Hopkins APL Tech. Dig., vol. 9, pp. 16-21, 1988.
K. Arshak, E. Jafer, G. Lyons, D. Morris, and O. Korostynska, "A review of low-power wireless sensor microsystems for biomedical capsule diagnosis, " Microelectron. Int., vol. 21, no. 3, pp. 8-19, 2004.
J. E. Pandolfino, J. E. Richter, T. Ours, J. M. Guardino, J. Chapman, and P. J. Kahrilas, "Ambulatory esophageal pH monitoring using a wireless system, " Amer. J. Gastroenterol., vol. 98, no. 4, pp. 740-749, Apr. 2003.
P. Mostafalu and S. Sonkusale, "Flexible and transparent gastric battery: Energy harvesting from gastric acid for endoscopy application, " Biosensors Bioelectron., vol. 54, pp. 292-296, Apr. 2014.
B. Lenaerts and R. Puers, "An inductive power link for a wireless endoscope, " Biosensors Bioelectron., vol. 22, no. 7, pp. 1390-1395, Feb. 2007.
R. R. Richardson, J. A. Miller, andW. M. Reichert, "Polyimides as biomaterials: Preliminary biocompatibility testing, " Biomaterials, vol. 14, no. 8, pp. 627-635, Jul. 1993.
P. Starr, C. M. Agrawal, and S. Bailey, "Biocompatibility of common polyimides with human endothelial cells for a cardiovascular microsensor, " J. Biomed. Mater. Res. A, vol. 104, no. 2, pp. 406-412, Feb. 2016.
M. S. Arefin, M. B. Coskun, T. Alan, J.-M. Redoute, A. Neild, and M. R. Yuce, "A microfabricated fringing field capacitive pH sensor with an integrated readout circuit, " Appl. Phys. Lett., vol. 104, no. 22, Jun. 2014, Art. no. 223503.
M. S. Arefin, M. B. Coskun, T. Alan, J. M. Redoute, A. Neild, and M. R. Yuce, "A MEMS capacitive pH sensor for high acidic and basic solutions, " in Proc. IEEE Sensors Conf., Valencia, Spain, Nov. 2-5, 2014, pp. 1792-1794.
M. S. Arefin, J.-M. Redoute, andM. R. Yuce, "A MEMS interface IC with low-power and wide-range frequency-to-voltage converter for biomedical applications, " IEEE Trans. Biomed. Circuits Syst., vol. 10, no. 2, pp. 455-466, Apr. 2016.
M. S. Arefin, J.-M. Redoute, and M. R. Yuce, "A low-power and widerange MEMS capacitive sensors interface IC using pulse-width modulation for biomedical applications, " IEEE Sensors J., vol. 16, no. 17, pp. 6745-6754, Sep. 2016.
M. S. Arefin, J.-M. Redoute, and M. R. Yuce, "Meandered conformal antenna for ISM-band ingestible capsule communication systems, " in Proc. IEEE 38th Annu. Int. Conf. Eng. Med. Biol. Soc., Orlando, FL, USA, Aug. 16-20, 2016, pp. 3031-3034.
Silicon labs microcontroller with transceiver Si1064. [Online]. Available: https://www. silabs. com/Support%20Documents/TechnicalDocs/Si106x-8x. pdf, Accessed on: Mar. 30, 2017.
T. C. Martinsen, K. Bergh, and H. L. Waldum, "Gastric juice: A barrier against infectious diseases, " Basic Clin. Pharmacol. Toxicol., vol. 94, no. 2, pp. 94-102, Feb. 2005.
Y. Kim, G. Lee, S. Park, B. Kim, J.-O. Park, and J.-H. Cho, "Pressure monitoring system in gastro-intestinal tract, " in Proc. IEEE Int. Conf. Robot. Autom., Apr. 18-22, 2005, pp. 1321-1326.
Microfab packaged pressure sensor Die E1. 3N. [Online]. Available: http://www. microfab. de/mems/pressuresensors/pressuresensorpackageddie/, Accessed on: Mar. 30, 2017.
Honeywell NTC thermistor 100 K? bead 192-104QET-A01. [Online]. Available: http://sensing. honeywell. com/192-104QET-A01-Discrete-Thermistors/, Accessed on: Mar. 30, 2017.
H. Wang, C.-C. Weng, and A. Hajimiri, "Phase noise and fundamental sensitivity of oscillator-based reactance sensors, " IEEE Trans. Microw. Theory Techn., vol. 61, no. 5, pp. 2215-2229, May 2013.
A. Kiourti, K. A. Psathas, and K. S. Nikita, "Implantable and ingestible medical devices with wireless telemetry functionalities: A review of current status and challenges, " Bioelectromagnetics, vol. 35, no. 1, pp. 1-15, Jan. 2014.
M. R. Yuce, T. Dissanayake, and H. C. Keong, "Wireless telemetry for electronic pill technology, " in Proc. IEEE Sensors Conf., Oct. 2009, pp. 1433-1438.
Johanson technology 433 MHZ impedance matched balun and band-pass filter SMD passive (0433BM41A0019). [Online]. Available: http://www. johansontechnology. com/datasheets/chipset-specific/0433BM41A0019. pdf/, accessed on Mar. 30, 2017.
Dow corning 3145 RTV-clear MIL-A-46146 adhesive/sealant. [Online]. Available: http://www. dowcorning. com/applications/search/default. aspx? R=146EN, Accessed on: Mar. 30, 2017.
Silicon labs single-chip USB to UART bridge CP2102. [Online]. Available: https://www. silabs. com/Support%20Documents/TechnicalDocs/CP2102-9. pdf, Accessed on: Mar. 30, 2017.
L. Xu, M. Q-H. Meng, H. Ren, and Y. Chan, "Radiation characteristics of ingestible wireless devices in human intestine following radio frequency exposure at 430, 800, 1200, and 2400 MHz, " IEEE Trans. Antennas Propag., vol. 57, no. 8, pp. 2418-2428, Aug. 2009.
F.-J. Huang, C.-M. Lee, C.-L. Chang, L.-K. Chen, T.-C. Yo, and C.-H. Luo, "Rectenna application ofminiaturized implantable antenna design for triple-band biotelemetry communication, " IEEE Trans. Antennas Propag., vol. 59, no. 7, pp. 2646-2653, Jul. 2011.
L. S. Xu, M. Q. H. Meng, and C. Hu, "Effects of dielectric values of human body on specific absorption rate following 430, 800, and 1200 MHz RF exposure to ingestible wireless device, " IEEE Trans. Inf. Technol. Biomed., vol. 14, no. 1, pp. 52-59, Jan. 2010.