Article (Scientific journals)
Positioning Europe for the EPITRANSCRIPTOMICS challenge
Jantsch, Michael F; Quattrone, Alessandro; O'Connell, Mary et al.
2018In RNA Biology, 15
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Keywords :
database of Modification; detection of RNA modification; epitranscriptomics; European funding; model systems
Abstract :
[en] The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Jantsch, Michael F
Quattrone, Alessandro
O'Connell, Mary
Willems, Luc  ;  Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Microbial, food and biobased technologies
Ule, Jernej
Fray, Rupert
Language :
English
Title :
Positioning Europe for the EPITRANSCRIPTOMICS challenge
Publication date :
2018
Journal title :
RNA Biology
ISSN :
1547-6286
eISSN :
1555-8584
Publisher :
Landes Bioscience, United States
Volume :
15
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
COST Action, (CA16120)
Available on ORBi :
since 04 February 2019

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