Article (Scientific journals)
Better outcome with haploidentical over HLA-matched related donors in patients with Hodgkin's lymphoma undergoing allogeneic haematopoietic cell transplantation - A study by the Francophone Society of Bone Marrow Transplantation and Cellular Therapy
Gauthier, J.; Poiré, X.; Gac, A.-C. et al.
2018In Bone Marrow Transplantation, 53 (4), p. 400-409
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Keywords :
Article; HLA matching; Hodgkin disease
Abstract :
[en] The question of the best donor type between haploidentical (HAPLO) and matched-related donors (MRD) for patients with advanced HL receiving an allogeneic hematopoietic cell transplantation (allo-HCT) is still debated. Given the lack of data comparing these two types of donor in the setting of non-myeloablative (NMA) or reduced-intensity (RIC) allo-HCT, we performed a multicentre retrospective study using graft-vs.-host disease-free relapse-free survival (GRFS) as our primary endpoint. We analysed the data of 151 consecutive HL patients who underwent NMA or RIC allo-HCT from a HAPLO (N = 61) or MRD (N = 90) between January 2011 and January 2016. GRFS was defined as the probability of being alive without evidence of relapse, grade 3-4 acute GVHD or chronic GVHD. In multivariable analysis, MRD donors were independently associated with lower GRFS compared to HAPLO donors (HR = 2.95, P < 0.001). Disease status at transplant other than CR was also associated with lower GRFS in multivariable analysis (HR = 1.74, P = 0.01). In addition, the administration of ATG was independently linked to higher GRFS (HR = 0.52, P = 0.009). In summary, we observed significantly higher GRFS in HL patients receiving an allo-HCT using the HAPLO PT-Cy platform compared to MRD. © 2017 Macmillan Publishers Ltd., part of Springer Nature.
Disciplines :
Hematology
Author, co-author :
Gauthier, J.;  Department of Hematology, CHRU Lille, Lille, France
Poiré, X.;  Section of Haematology, Clinique Universitaire de St-Luc, Brussels, Belgium
Gac, A.-C.;  Department of Haematology, Caen University Hospital France, Caen, France
Leclerc, M.;  Department of Haematology, Henri-Mondor Hospital, APHP, Paris, France
Guillaume, T.;  Department of Haematology, Nantes University Hospital, Nantes, France
Chalandon, Y.;  Haematology Service Oncology Department, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
Nguyen, S.;  Department of Haematology, Pitié Salpêtrière Hospital, APHP, Paris, France
Forcade, E.;  Department of Haematology and Cellular Therapy, University Hospital Bordeaux, Bordeaux, France
Régny, C.;  Department of Haematology, Grenoble University Hospital, Grenoble, France
Bay, J.-O.;  Department of Haematology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France
Bazarbachi, A.;  Bone Marrow Transplant Department, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
Rohrlich, P.-S.;  Department of Haematology, Nice University Hospital, Nice, France
Huynh, A.;  Department of Haematology, Toulouse University Hospital, Toulouse, France
Farhi, J.;  Department of Haematology, Angers University Hospital France, Angers, France
Marchand, T.;  Department of Haematology, Rennes University Hospital, Rennes, France
Malfuson, J.-V.;  Department of Haematology, Percy Hospital, Clamart, France
Pilorge, S.;  Haematological Early Drug Development Department, Gustave Roussy Institute, Paris, France
Labussière-Wallet, H.;  Department of Haematology, Lyon University Hospital, Lyon, France
Renard, C.;  Haematology and Pediatric Oncology Institute, Lyon University Hospital, Lyon, France
Fornecker, L.-M.;  Department of Haematology, Strasbourg University Hospital, Strasbourg, France
Detrait, M.;  Haematology Department, Nancy University Hospital, Nancy, France
Duléry, R.;  Department of Haematology, Saint-Antoine Hospital, APHP, Paris, France
Delage, J.;  Department of Haematology, Montpellier University Hospital, Montpellier, France
Ménard, A.-L.;  Henri Becquerel Centre, Rouen, France
Charbonnier, A.;  Department of Haematology, Amiens University Hospital, Amiens, France
Nelken, B.;  Department of Paediatric Haematology, Lille University Hospital, Lille, France
Jubert, C.;  Pediatric Haematology Department, Bordeaux University Hospital, Bordeaux, France
Suarez, F.;  Department of Haematology, Necker Hospital, APHP, Paris, France
De La Tour, R. P.;  Department of Haematology, Saint-Louis Hospital, APHP, Paris, France
Beguin, Yves  ;  Université de Liège - ULiège > GIGA-R : Hématologie
Schoemans, H.;  Department of Haematology, Catholic University of Leuven, Leuven, Belgium
Blaise, D.;  Department of Haematology, Paoli-Calmettes Institute, Marseille, France
Yakoub-Agha, I.;  CHRU Lille, Pôle Spécialités Médicales et Gérontologie, Medical Specialities and Gerontology, Service des Maladies du Sang, Department of Haematology, Secteur Allogreffe de Cellules Souches Hématopoïétiques, Allogeneic Stem Cell Transplantation Department, Lille, F59037, France, Université de Lille, Lille University, UFR Médecine, Lille, F59000, France, LIRIC INSERM U995, Lille, 59000, France
More authors (23 more) Less
Language :
English
Title :
Better outcome with haploidentical over HLA-matched related donors in patients with Hodgkin's lymphoma undergoing allogeneic haematopoietic cell transplantation - A study by the Francophone Society of Bone Marrow Transplantation and Cellular Therapy
Publication date :
2018
Journal title :
Bone Marrow Transplantation
ISSN :
0268-3369
eISSN :
1476-5365
Publisher :
Nature Publishing Group
Volume :
53
Issue :
4
Pages :
400-409
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 January 2019

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