Cytological and cytochemical analysis of the effects of cis-dichlorodiamino platinum (II) on chick fibroblasts cultivated in vitro.

Heinen, Ernst; Bassleer, Roger

doi:10.1159/000221932

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Cytological and cytochemical analysis of the effects of cis-dichlorodiamino platinum (II) on chick fibroblasts cultivated in vitro.

Heinen, Ernst; Bassleer, Roger

1976 • In Chemotherapy, 22 (3-4), p. 253-61

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/23190

DOI
10.1159/000221932

PubMed
1269291

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Keywords :

Animals; Cell Division/drug effects; Cell Nucleolus/drug effects/ultrastructure; Chick Embryo; Chromatin/drug effects; Cisplatin/toxicity; Cytoplasm/drug effects; DNA/biosynthesis; Fibroblasts/drug effects/metabolism/ultrastructure; Mitosis/drug effects; RNA/biosynthesis

Abstract :

[en] Chick embryo fibroblasts cultivated in vitro and treated with cis-dichlorodiamino platinum (II) have been analysed by cytological and cytochemical methods. Morphological alterations (in the nucleoli, in the chromatin and in the cytoplasm), inhibition of DNA and RNA syntheses and of cell multiplication have been noted. Under some conditions, cells are blocked just before entering into mitosis (G2 block) and can become polyploid. A high degree of cell degeneration has also been observed.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Heinen, Ernst ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine

Bassleer, Roger ; Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)

Language :

English

Title :

Cytological and cytochemical analysis of the effects of cis-dichlorodiamino platinum (II) on chick fibroblasts cultivated in vitro.

Publication date :

1976

Journal title :

Chemotherapy

ISSN :

0009-3157

eISSN :

1421-9794

Publisher :

S. Karger

Volume :

Issue :

3-4

Pages :

253-61

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 24 September 2009

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Bibliography

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