Reference : Effectiveness of a Malaria Surveillance Strategy based on active case detection durin...
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
Human health sciences : Public health, health care sciences & services
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/231453
Effectiveness of a Malaria Surveillance Strategy based on active case detection during high transmission season in the Peruvian Amazon
English
[en] Efficacité de la stratégie de surveillance de la malaria fondée sur la détection active durant la haute saison de transmisison dans la région amazonienne au Pérou
Moreno-Gutierrez, Diamantina mailto []
Llanos-Cuentas, Alejandro []
Barboza, José Luis []
Contreras-Mancilla, Juan []
Gamboa, Dionicia []
Rodriguez, Hugo []
Carrasco-Escobar, Gabriel []
BOREUX, Raphaël mailto [Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire biologie moléculaire >]
Hayette, Marie-Pierre mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Bactériologie, mycologie, parasitologie, virologie >]
Beutels, Philippe []
Speybroeck, Niko mailto []
Rosas-Aguirre, Angel mailto []
27-Nov-2018
International Journal of Environmental Research and Public Health
Multidisciplinary Digital Publishing Institute (MDPI)
15
2670
Yes (verified by ORBi)
International
1660-4601
1661-7827
Switzerland
[en] malaria ; diagnosis ; asymptomatic ; active detection ; Peru
[en] Background: Faced with the resurgence of malaria, malaria surveillance in the Peruvian
Amazon incorporated consecutive active case detection (ACD) interventions using light microscopy
(LM) as reactive measure in communities with an unusual high number of cases during high
transmission season (HTS). We assessed the effectiveness in malaria detection of this local
ACD-based strategy. Methods: A cohort study was conducted in June–July 2015 in Mazan, Loreto.
Four consecutive ACD interventions at intervals of 10 days were conducted in four riverine
communities (Gamitanacocha, Primero de Enero, Libertad and Urco Miraño). In each intervention,
all inhabitants were visited at home, and finger-prick blood samples collected for immediate diagnosis by LM and on filter paper for later analysis by quantitative real-time polymerase chain reaction (qPCR). Effectiveness was calculated by dividing the number of malaria infections detected using LM by the number of malaria infections detected by delayed qPCR. Results: Most community inhabitants (88.1%, 822/933) were present in at least one of the four ACD interventions. A total of 451 infections were detected by qPCR in 446 participants (54.3% of total participants); five individuals had two infections. Plasmodium vivax was the predominant species (79.8%), followed by P. falciparum (15.3%) and P. vivax-P. falciparum co-infections (4.9%). Most qPCR-positive infections were asymptomatic (255/448, 56.9%). The ACD-strategy using LM had an effectiveness of 22.8% (detection of 103 of the total qPCR-positive infections). Children aged 5–14 years, and farming as main economic activity were associated with P. vivax infections. Conclusions: Although the ACD-strategy using LM increased the opportunity of detecting and treating malaria infections during HTS, the number of detected infections was considerably lower than the real burden of infections (those detected by qPCR).
Peruvian National Council of Science and ARES CCD
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/231453
10.3390/ijerph15122670

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