The functional diversity of Aurora kinases: a comprehensive review

[en] Aurora kinases are serine/threonine kinases essential for the onset and progression of mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit distinct cellular and subcellular localization. AurA favors the G2/M transition by promoting centrosome maturation and mitotic spindle assembly. AurB and AurC are chromosome-passenger complex proteins, crucial for chromosome binding to kinetochores and segregation of chromosomes. Cellular distribution of AurB is ubiquitous, while AurC expression is mainly restricted to meiotically-active germ cells. In human tumors, all Aurora kinase members play oncogenic roles related to their mitotic activity and promote cancer cell survival and proliferation. Furthermore, AurA plays tumor-promoting roles unrelated to mitosis, including tumor stemness, epithelial-to-mesenchymal transition and invasion. In this review, we aim to understand the functional interplay of Aurora kinases in various types of human cells, including tumor cells. The understanding of the functional diversity of Aurora kinases could help to evaluate their relevance as potential therapeutic targets in cancer.

Disciplines :

Oncology

Author, co-author :

Willems, Estelle ; Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (paysage)

Dedobbeleer, Matthias ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine

Di Gregorio, Marina ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

LOMBARD, Arnaud ; Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Service de chirurgie de l'appareil locomoteur

Lumapat, Paul Noel ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine

ROGISTER, Bernard ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de neurologie

Language :

English

Title :

The functional diversity of Aurora kinases: a comprehensive review

Publication date :

2018

Journal title :

Cell Division

eISSN :

1747-1028

Publisher :

BioMed Central, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 12 January 2019

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214

Scopus citations^®
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214

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183

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