solvent extraction; process intensification; process integration; multiphase separation; single-drop experiments
Abstract :
[en] BACKGROUND: Extraction is the method of choice for separating sensitive products. For example, it has been applied in
aromatics and rare-earth metal separation. Recently, biotechnological processes entered the field of bulk chemicals andmight
benefit fromprocess intensification by in situ extraction of inhibiting products, however in the presence of cells and/or aeration.
This study applies reactive extraction of the polyamide monomer hexane-1,6-diamine fromcell-containingmedium.
RESULTS: To prove technical feasibility of this reactive extraction, simulation of the extraction column based on single-drop
measurements was validated at pilot-scale. Simulated results show good accordance with experimental data with an error
below 20%. The extraction column was subsequently used as a bioreactor with integrated aeration and product extraction
applying a four-phase system investigating the effect on drop distributions and holdup of the dispersed phases. Interestingly,
aeration increased the holdup up to five-fold and decreased themean drop size of the organic extractive phase by 30%, thereby
potentially improving extraction efficiency.
CONCLUSION: The ReDrop simulation tool is capable of predicting challenging separation processes like the reactive extraction
of hexane-1,6-diamine with D2EHPA diluted in oleyl alcohol from a biotransformation medium. The process design enabled
four-phase operation of the column with aeration, extractive organic phase and cell-containing continuous aqueous phase.
Disciplines :
Chemical engineering
Author, co-author :
Bednarz, Andreas
Jupke, Andreas
Spieß, Antje C.
Pfennig, Andreas ; Université de Liège - ULiège > Department of Chemical Engineering > PEPs - Products, Environment, and Processes
Language :
English
Title :
Aerated extraction columns for in situ separation of bio-based diamines from cell suspensions
Publication date :
2019
Journal title :
Journal of Chemical Technology and Biotechnology
ISSN :
0268-2575
Publisher :
John Wiley & Sons, Hoboken, United States - New Jersey
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Pfennig A, Pilhofer T and Schröter J, Flüssig-Flüssig-Extraktion, in Fluidverfahrenstechnik, ed. by Goedecke R. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, pp. 907–992 (2006)
Bednarz A, Scherübel P, Spieß AC and Pfennig A, Optimization of settling behavior for an efficient solvent-extraction process for bio-based components. Chem Eng Technol 40:1852–1860 (2017)
Mohanty S, Modeling of liquid-liquid extraction column: a review. Rev Chem Eng 16:199–248 (2000)
Chen HT and Middleman S, Drop size distribution in agitated liquid-liquid systems. AIChE J 13:989–995 (1967)
Pilhofer T, Verfahrenstechnische Auslegung von Flüssig-Flüssig-Gegenstromkolonnen. Habilitationsschrift, TU München, Germany (1978)
Seibert AF and Fair JR, Hydrodynamics and mass transfer in spray and packed liquid-liquid extraction columns. Ind Eng Chem Res 27:470–481 (1988)
Kumar A and Hartland S, A unified correlation for the prediction of dispersed-phase hold-up in liquid-liquid extraction columns. Ind Eng Chem Res 34:3925–3940 (1995)
Kind M, Mersmann A and Stichlmair J, Thermische Verfahrenstechnik: Grundlagen und Methoden. Springer, Berlin (2005)
Weinstein O and Semiat R, Lewin. Modeling, simulation and control of liquid-liquid extraction columns. Chem Eng Sci 53:325–339 (1998)
Lao M, Kingsley JP, Krishnamurthy R and Taylor R, A nonequilibrium stage model of multicomponent separation processes VI: simulation of liquid-liquid extraction. Chem Eng Commun 86:73–89 (1989)
Kumar A and Hartland S, Unified correlations for the prediction of drop size in liquid-liquid extraction columns. Ind Eng Chem Res 35:2682–2695 (1996)
Saboni A and Alexandrova S, Numerical study of the drag on a fluid sphere. AIChE J 48:2992 (2002)
Thorsen G, Stordalen RM and Terjesen SG, On the terminal velocity of circulating and oscillating liquid drops. Chem Eng Sci 23:413–426 (1968)
Hamielec AE, Storey SH and Whitehead JM, Viscous flow around fluid spheres at intermediate Reynolds numbers (II). Can J Chem Eng 41:246–251 (1963)
Feng Z-G and Michaelides EE, Drag coefficients of viscous spheres at intermediate and high Reynolds numbers. J Fluids Eng 123:841–849 (2001)
Ishii M and Zuber N, Drag coefficient and relative velocity in bubbly, droplet or particulate flows. AIChE J 25:843–855 (1979)
Henschke M and Pfennig A, Mass-transfer enhancement in single-drop extraction experiments. AIChE J 45:2079–2086 (1999)
Handlos AE and Baron T, Mass and heat transfer from drops in liquid-liquid extraction. AIChE J 3:127–136 (1957)
Kronig R and Brink JC, On the theory of extraction from falling droplets. Appl Sci Res 2:142–154 (1951)
Attarakih MM, Bart H-J, Steinmetz T, Dietzen M and Faqir NM, LLECMOD: a bivariate population balance simulation tool for liquid-liquid extraction columns. Open Chem Eng J 2:10–34 (2008)
Kumar A and Hartland S, Computational strategies for sizing liquid-liquid extractors. Ind Eng Chem Res 38:1040–1056 (1999)
Buchbender F, Schmidt M, Steinmetz T and Pfennig A, Simulation von Extraktionskolonnen in der industriellen Praxis. Chemie Ingenieur Technik 84:540–546 (2012)
Ayesterán J, Kopriwa N, Buchbender F, Kalem M and Pfennig A, ReDrop - a simulation tool for the design of extraction columns based on single-drop experiments. Chem Eng Technol 38:1894–1900 (2015)
Altunok M, Grömping T, Pfennig A, ReDrop—An efficient simulation tool for describing solvent and reactive extraction columns, in 16th European Symposium on Computer Aided Process Engineering and 9th International Symposium on Process Systems Engineering, Computer Aided Chemical Engineering, Elsevier, pp. 665–670 (2006)
Kalem M, Buchbender F and Pfennig A, Simulation of hydrodynamics in RDC extraction columns using the simulation tool “ReDrop”. Chem EngResDesign 89:1–9 (2011)
Klement T, Milker S, Jäger G, Grande PM, Domínguez de María P and Büchs J, Biomass pretreatment affects Ustilago maydis in producing itaconic acid. Microb Cell Fact 11:43 (2012)
Polen T, Spelberg M and Bott M, Toward biotechnological production of adipic acid and precursors from biorenewables. J Biotechnol 167:75–84 (2013)
Eggeman T and Verser D, Recovery of organic acids from fermentation broths. Appl Biochem Biotechnol 121–124:605–618 (2005)
Alkaya E, Kaptan S, Ozkan L, Uludag-Demirer S and Demirer GN, Recovery of acids from anaerobic acidification broth by liquid-liquid extraction. Chemosphere 77:1137–1142 (2009)
Cascaval D, Oniscu C and Galaction A-I, Selective separation of amino acids by reactive extraction. Biochem Eng J 7:171–176 (2001)
Dinculescu D, Guzun-Stoica A, Dobre T and Floarea O, Experimental investigation of citric acid reactive extraction with solvent recycling. Bioprocess Eng 22:529–531 (2000)
Gu Z, Glatz BA and Glatz CE, Propionic acid production by extractive fermentation. I. Solvent considerations. Biotechnol Bioeng 57:454–461 (1998)
Hong KH, Hong WH and Han DH, Application of reactive extraction to recovery of carboxylic acids. Biotechnol Bioprocess Eng 6:386–394 (2001)
Kurzrock T and Weuster-Botz D, New reactive extraction systems for separation of bio-succinic acid. Bioprocess Biosyst Eng 34:779–787 (2011)
Dai J-Y, Liu C-J and Xiu Z-L, Sugaring-out extraction of 2, 3-butanediol from fermentation broths. Process Biochem 50:1951–1957 (2015)
Koutinas AA, Yepez B, Kopsahelis N, Freire DMG, de Castro AM, Papanikolaou S et al., Techno-economic evaluation of a complete bioprocess for 2, 3-butanediol production from renewable resources. Bioresour Technol 204:55–64 (2016)
Li Z, Teng H and Xiu Z, Aqueous two-phase extraction of 2, 3-butanediol from fermentation broths using an ethanol/ammonium sulfate system. Process Biochem 45:731–737 (2010)
Shao P and Kumar A, Recovery of 2, 3-butanediol from water by a solvent extraction and pervaporation separation scheme. J Membr Sci 329:160–168 (2009)
Xiu Z-L and Zeng A-P, Present state and perspective of downstream processing of biologically produced 1, 3-propanediol and 2, 3-butanediol. Appl Microbiol Biotechnol 78:917–926 (2008)
Li Y, Wu Y, Zhu J, Liu J and Shen Y, Separating 2,3-butanediol from fermentation broth using n-butylaldehyde. J Saudi Chem Soc 20:S495–S502 (2016)
Anvari M, Khayati G, Pahlavanzadeh H and Vasheghani-Farahani E, In situ recovery of 2,3-butanediol from fermentation by liquid–liquid extraction. J Indus Microbiol Biotechnol 36:313–317 (2009)
Li Y, Wu Y, Zhu J and Liu J, Separation of 2,3-butanediol from fermentation broth by reactive extraction using acetaldehyde-cyclohexane system. Biotechnol Bioprocess Eng 17:337–345 (2012)
Krzyżaniak A, Schuur B and de Haan AB, Extractive recovery of aqueous diamines for bio-based plastics production. J Chem Technol Biotechnol 88:1937–1945 (2013)
Krzyżaniak A, Tansaz A, Schuur B and de Haan AB, Equilibrium studies on butane-1,4-diamine extraction with 4-nonylphenol. J Chem Technol Biotechnol 89:1015–1022 (2014)
Kind S, Neubauer S, Becker J, Yamamoto M, Völkert M, von Abendroth G et al., From zero to hero-production of bio-based nylon from renewable resources using engineered Corynebacterium glutamicum. Metab Eng 25:113–123 (2014)
Wittmann C, Kind S, Processes and recombinant microorganisms for the production of cadaverine. Google Patents, US Patent 9745608 (2017)
Ma W, Chen K, Li Y, Hao N, Wang X and Ouyang P, Advances in cadaverine bacterial production and its applications. Engineering 3:308–317 (2017)
Suominen LH, Galleher CJ, Japs M, Burk MJ, Tracewell C, Method of producing & processing diamines. Google Patents, US Patent 15/538448 (2017)
Job C and Blass E, Problems concerning liquid-liquid extraction of extracellular products directly from fermenter broths. Chem Eng J 56:B1–B8 (1994)
Job C and Blass E, Methods for characterization the hydrodynamic behaviour of fermenter broths in liquid-liquid extractors, in Process Metallurgy, Vol. 7. Elsevier, pp. 1893–1898 (1992)
Job C, Schertler C, Staudenbauer WL and Blass E, Selection of organic solvents for in situ extraction of fermentation products from Clostridium Thermohydrosulfuricum cultures. Biotechnol Technol 3:315–320 (1989)
Bednarz A, Spieß AC and Pfennig A, Reactive and physical extraction of bio-based diamines from fermentation media. J Chem Technol Biotechnol 135:422 (2017)
Liu J, Shi M, Diosady LL and Rubin LJ, Three-phase extraction of Chinese rapeseed using the Karr column. J Food Eng 24:35–45 (1995)
Wilke CR and Chang P, Correlation of diffusion coefficients in dilute solutions. AIChE J 1:264–270 (1955)
Altunok MY, Kalem M and Pfennig A, Investigation of mass transfer on single droplets for the reactive extraction of zinc with D2EHPA. AIChE J 58:1346–1355 (2012)
Herbert P, Santos L and Alves A, Simultaneous quantification of primary, secondary amino acids, and biogenic amines in musts and wines using OPA/3-MPA/FMOC-CI fluorescent derivatives. J Food Sci 66:1319–1325 (2001)
Henschke M, Waheed A and Pfennig A, Wandeinfluss auf die Sedimentationsgeschwindigkeit von Kugeln. Chemie Ingenieur Technik 72:1376–1380 (2000)
Henschke M, Auslegung pulsierter Siebboden-Extraktionskolonnen. Shaker, Herzogenrath, Germany (2004)
Arimont K, Soika M and Henschke M, Simulation einer pulsierten Füllkörperextraktionskolonne. Chemie Ingenieur Technik. 68:276–279 (1996)
Buchbender F, Onink F, Meindersma W, de Haan A and Pfennig A, Simulation of aromatics extraction with an ionic liquid in a pilot-plant Kühni extractor based on single-drop experiments. Chem Eng Sci 82:167–176 (2012)
Buchbender F, Fischer A and Pfennig A, Influence of compartment geometry on the residence time of single drops in Kühni extraction columns. Chem Eng Sci 104:701–716 (2013)
Karr AE, Design, scale-up, and applications of the reciprocating plate extraction column. Sep Sci Technol 15:877–905 (1980)
Yih S-M, Wu Y-M, Pan R-K, Wu Y-F and Chen T-F, Holdup measurement in a Scheibel extraction column. Solvent Extraction Ion Exchange 5:353–365 (1987)
Klinger S, Messung und Modellierung des Spaltungs-und Koaleszenzverhaltens von Tropfen bei der Extraktion. PhD thesis, RWTH Aachen, Aachen (2008)
Adinata D, Ayesterán J, Buchbender F, Kalem M, Kopriwa N and Pfennig A, Tropfenpopulationsbilanzen zur Auslegung von Extraktionskolonnen. Chemie Ingenieur Technik 83:952–964 (2011)
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