Reference : The role of roughage provision on the absorption and disposition of the mycotoxin deo...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/231034
The role of roughage provision on the absorption and disposition of the mycotoxin deoxynivalenol and its acetylated derivatives in calves: from field observations to toxicokinetics.
English
Valgaeren, Bonnie* [> >]
Theron, Leonard* [> >]
Croubels, Siska [> >]
Devreese, Mathias [> >]
De Baere, Siegrid [> >]
Van Pamel, Els [> >]
Daeseleire, Els [> >]
De Boevre, Marthe [> >]
De Saeger, Sarah [> >]
Vidal, Arnau [> >]
Di Mavungu, Jose Diana [> >]
Fruhmann, Philipp [> >]
Adam, Gerhard [> >]
Callebaut, Alfons [> >]
Bayrou, Calixte mailto [Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Pathologie spéciale et autopsies >]
Frisee, Vincent mailto [Université de Liège - ULiège > Département clinique des animaux de production (DCP) > Département clinique des animaux de production (DCP) >]
Rao, Anne-Sophie mailto [Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Microbiologie des denrées alimentaires >]
Knapp, Emilie [> >]
Sartelet, Arnaud mailto [Université de Liège - ULiège > Département clinique des animaux de production (DCP) > Département clinique des animaux de production (DCP) >]
Pardon, Bart [> >]
Deprez, Piet [> >]
Antonissen, Gunther [> >]
* These authors have contributed equally to this work.
In press
Archives of Toxicology
Yes (verified by ORBi)
International
0340-5761
1432-0738
Germany
[en] 3- and 15-Acetyldeoxynivalenol ; Biodegradation ; Calf ; Deoxynivalenol ; Mycotoxin ; Toxicokinetics
[en] A clinical case in Belgium demonstrated that feeding a feed concentrate containing considerable levels of deoxynivalenol (DON, 1.13 mg/kg feed) induced severe liver failure in 2- to 3-month-old beef calves. Symptoms disappeared by replacing the highly contaminated corn and by stimulating ruminal development via roughage administration. A multi-mycotoxin contamination was demonstrated in feed samples collected at 15 different veal farms in Belgium. DON was most prevalent, contaminating 80% of the roughage samples (mixed straw and maize silage; average concentration in positives: 637 +/- 621 microg/kg, max. 1818 microg/kg), and all feed concentrate samples (411 +/- 156 microg/kg, max. 693 microg/kg). In order to evaluate the impact of roughage provision and its associated ruminal development on the gastro-intestinal absorption and biodegradation of DON and its acetylated derivatives (3- and 15-ADON) in calves, a toxicokinetic study was performed with two ruminating and two non-ruminating male calves. Animals received in succession a bolus of DON (120 microg/kg bodyweight (BW)), 15-ADON (50 microg/kg BW), and 3-ADON (25 microg/kg) by intravenous (IV) injection or per os (PO) in a cross-over design. The absolute oral bioavailability of DON was much higher in non-ruminating calves (50.7 +/- 33.0%) compared to ruminating calves (4.1 +/- 4.5%). Immediately following exposure, 3- and 15-ADON were hydrolysed to DON in ruminating calves. DON and its acetylated metabolites were mainly metabolized to DON-3-glucuronide, however, also small amounts of DON-15-glucuronide were detected in urine. DON degradation to deepoxy-DON (DOM-1) was only observed to a relevant extent in ruminating calves. Consequently, toxicity of DON in calves is closely related to roughage provision and the associated stage of ruminal development.
http://hdl.handle.net/2268/231034
10.1007/s00204-018-2368-8

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Valgaeren et al 2018 The role of roughage provision on the absorption and disposition of the mycotoxin deoxynivalenol and its acetylated derivatives in calves from field observations to toxicokinetics.pdfPublisher postprint1.77 MBView/Open

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