Article (Scientific journals)
Natural Products for Promoting Joint Health and Managing Osteoarthritis
Henrotin, Yves; Mobasheri, A.
2018In Current Rheumatology Reports, 20 (11), p. 72
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Keywords :
Boswellia serrata extract; Curcumin; Osteoarthritis; Plant extracts; Pycnogenol
Abstract :
[en] Purpose of Review: Osteoarthritis, the most common joint disease, is associated with substantial medical costs, lost productivity, and reduced quality of life. However, available pharmaceutical treatments have limitations in terms of efficacy and long-term safety. Recent Findings: In vitro evidence suggests that some natural products may possess anti-inflammatory and anti-oxidative properties and may inhibit the release of key osteoarthritis-related cytokines. There is, therefore, ongoing interest in identifying natural products that safely promote joint health and treat osteoarthritis. Numerous plant extracts, including curcumin, Boswellia extract, and pycnogenol, have shown effect sizes (ES) for reducing pain and functional disability larger than those observed with analgesics and products such as glucosamine and chondroitin. The ES for methylsulfonylmethane and avocado/soybean unsaponifiables are also considered to be clinically relevant. Summary: Data from a small number of studies using natural products for treating osteoarthritis are promising but require confirmation in further well-designed clinical trials. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Disciplines :
Rheumatology
Author, co-author :
Henrotin, Yves  ;  Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)
Mobasheri, A.;  Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania, Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, Queen’s Medical Centre, Nottingham, United Kingdom, School of Veterinary Medicine, University of Surrey, Guildford, Surrey, United Kingdom
Language :
English
Title :
Natural Products for Promoting Joint Health and Managing Osteoarthritis
Publication date :
2018
Journal title :
Current Rheumatology Reports
ISSN :
1523-3774
eISSN :
1534-6307
Publisher :
Current Medicine Group LLC 1
Volume :
20
Issue :
11
Pages :
72
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Pfizer [US-NY]
Arthritis Research UK
UE - Union Européenne [BE]
MSD - Merck Sharp and Dohme [BE]
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since 07 January 2019

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