Statin therapy modulates thickness and inflammatory profile of human epicardial adipose tissue

[en] Background: Epicardial adipose tissue (EAT) thickness and pro-inflammatory status has been shown to be associated with several cardiac diseases, including aortic stenosis (AS). Thus, cardiac visceral fat could represent a potential new target for drugs. In the present study we evaluate the effect of statin therapy on EAT accumulation and inflammation. Methods: Echocardiographic EAT thickness was assessed in 193 AS patients taking (n.87) and not taking (n.106) statins, undergoing cardiac surgery. To explore the association between statin therapy and EAT inflammation, EAT biopsies were obtained for cytokines immunoassay determination in EAT secretomes. An in vitro study was also conducted and the modulation of EAT and subcutaneous adipose tissue (SCAT) secretomes by atorvastatin was assessed in paired biopsies. Results: Statin therapy was significantly associated with lower EAT thickness (p < 0.0001) and with lower levels of EAT-secreted inflammatory mediators (p < 0.0001). Of note, there was a significant correlation between EAT thickness and its pro-inflammatory status. In vitro, atorvastatin showed a direct anti-inflammatory effect on EAT which was significantly higher compared to the SCAT response to statin incubation (p < 0.0001). Conclusions: The present study indicates a robust association between statin therapy and reduced EAT accumulation in patients with AS. The present data also suggest a direct relationship between EAT thickness and its inflammatory status, both modulated by statin therapy. The in vitro results support the hypothesis of a direct action of statins on EAT secretory profile. Overall our data suggest EAT as a potential new therapeutic target for statin therapy. © 2018 Elsevier B.V.

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Parisi, V.; Department of Translational Medical Science, University of Naples Federico II, Italy

Petraglia, L.; Department of Translational Medical Science, University of Naples Federico II, Italy

D'Esposito, V.; Department of Translational Medical Science, University of Naples Federico II, Italy

Cabaro, S.; Department of Translational Medical Science, University of Naples Federico II, Italy

Rengo, G.; Department of Translational Medical Science, University of Naples Federico II, Italy

Caruso, A.; Casa di Cura San Michele, MaddaloniCE, Italy

Grimaldi, M. G.; Casa di Cura San Michele, MaddaloniCE, Italy

Baldascino, F.; Casa di Cura San Michele, MaddaloniCE, Italy

De Bellis, A.; Casa di Cura San Michele, MaddaloniCE, Italy

Vitale, D.; Casa di Cura San Michele, MaddaloniCE, Italy

More authors (9 more)

Language :

English

Title :

Statin therapy modulates thickness and inflammatory profile of human epicardial adipose tissue

Publication date :

2019

Journal title :

International Journal of Cardiology

ISSN :

0167-5273

eISSN :

1874-1754

Publisher :

Elsevier Ireland Ltd

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 21 December 2018

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